Cancer mortality among French Atomic Energy Commission workers

Background All causes and cancer mortality of 58,320 workers employed at the Commissariat à l'Energie Atomique (CEA) between 1946 and 1994 were compared with that of the general population in a retrospective cohort study. Methods Standardized Mortality Ratios (SMR) were computed with reference...

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Bibliographic Details
Published in:American journal of industrial medicine 2004-01, Vol.45 (1), p.34-44
Main Authors: Telle-Lamberton, M., Bergot, D., Gagneau, M., Samson, E., Giraud, J.M., Néron, M.O., Hubert, P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
asbestos
Biological and medical sciences
cancer
Cause of Death
Cohort Studies
Epidemiology
Female
Follow-Up Studies
France - epidemiology
Humans
ionizing radiation
Male
Medical sciences
Middle Aged
mortality
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - mortality
Nuclear Energy
nuclear workers
Occupational Diseases - epidemiology
Occupational Diseases - mortality
occupational epidemiology
Occupational Exposure - adverse effects
Power Plants - manpower
Radiation Dosage
Risk Factors
Tumors
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Summary:Background All causes and cancer mortality of 58,320 workers employed at the Commissariat à l'Energie Atomique (CEA) between 1946 and 1994 were compared with that of the general population in a retrospective cohort study. Methods Standardized Mortality Ratios (SMR) were computed with reference to the French national population. Results Between 1968 and 1994, 4,809 deaths occurred. A healthy worker effect is observed for men (SMR = 0.57, CI90% = [0.56;0.59]) and for women (SMR = 0.72, CI90% = [0.67;0.77]). Nine sites of cancer death were found to be in statistically significant deficit among men, none among women. An excess of pleural cancers is observed among men (SMR = 1.79, CI90% = [1.27;2.45]) and of malignant melanoma (SMR = 1.50, CI90% = [1.04;2.11]). An excess of breast cancer is observed among women on the borderline of significance (SMR = 1.14, CI90% = [0.94;1.37]). Conclusions Excesses observed will have to be related to occupational exposures in the on‐going cohort study on French nuclear workers which includes a retrospective exposures assessment. Am. J. Ind. Med. 45:34–44, 2004. © 2003 Wiley‐Liss, Inc.
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.10306