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Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients
Objects Alzheimer's disease (AD) is one of the most important diseases in aging society, and non‐drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add‐on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods We retrospectively analy...
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| Published in: | Geriatrics & gerontology international 2016-02, Vol.16 (2), p.200-204 |
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| container_title | Geriatrics & gerontology international |
| container_volume | 16 |
| creator | Matsuzono, Kosuke Hishikawa, Nozomi Takao, Yoshiki Wakutani, Yosuke Yamashita, Toru Deguchi, Kentaro Abe, Koji |
| description | Objects
Alzheimer's disease (AD) is one of the most important diseases in aging society, and non‐drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add‐on effect of cognitive rehabilitation on AD patients under donepezil treatment.
Methods
We retrospectively analyzed 55 AD patients with a Mini‐Mental State Examination score of 15–25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D + R, n = 32) or not (group D, n = 23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1–2 h once or twice a week.
Results
Between group D and group D + R, there was no significant difference in baseline data, such as age, Mini‐Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1 mg/day). At 1 year later, however, the Mini‐Mental State Examination score improved only in group D + R from 21.7 to 24.0 (**P |
| doi_str_mv | 10.1111/ggi.12455 |
| format | article |
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Alzheimer's disease (AD) is one of the most important diseases in aging society, and non‐drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add‐on effect of cognitive rehabilitation on AD patients under donepezil treatment.
Methods
We retrospectively analyzed 55 AD patients with a Mini‐Mental State Examination score of 15–25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D + R, n = 32) or not (group D, n = 23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1–2 h once or twice a week.
Results
Between group D and group D + R, there was no significant difference in baseline data, such as age, Mini‐Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1 mg/day). At 1 year later, however, the Mini‐Mental State Examination score improved only in group D + R from 21.7 to 24.0 (**P < 0.001), whereas that of group D remained at 21.5 with both groups of donepezil 5.0 mg/day.
Conclusion
The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD patients than drug only therapy at 1 year. Geriatr Gerontol Int 2016; 16: 200–204.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.12455</identifier><identifier>PMID: 25656634</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Aged ; Alzheimer Disease - drug therapy ; Alzheimer Disease - rehabilitation ; Alzheimer's disease ; Cholinesterase Inhibitors - therapeutic use ; cognitive function ; cognitive rehabilitation ; Cognitive Therapy ; Combined Modality Therapy ; dementia ; donepezil ; Humans ; Indans - therapeutic use ; NMR ; Nuclear magnetic resonance ; Piperidines - therapeutic use ; Rehabilitation ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Geriatrics & gerontology international, 2016-02, Vol.16 (2), p.200-204</ispartof><rights>2015 Japan Geriatrics Society</rights><rights>2015 Japan Geriatrics Society.</rights><rights>Copyright © 2016 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25656634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuzono, Kosuke</creatorcontrib><creatorcontrib>Hishikawa, Nozomi</creatorcontrib><creatorcontrib>Takao, Yoshiki</creatorcontrib><creatorcontrib>Wakutani, Yosuke</creatorcontrib><creatorcontrib>Yamashita, Toru</creatorcontrib><creatorcontrib>Deguchi, Kentaro</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><title>Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients</title><title>Geriatrics & gerontology international</title><addtitle>Geriatrics & Gerontology International</addtitle><description>Objects
Alzheimer's disease (AD) is one of the most important diseases in aging society, and non‐drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add‐on effect of cognitive rehabilitation on AD patients under donepezil treatment.
Methods
We retrospectively analyzed 55 AD patients with a Mini‐Mental State Examination score of 15–25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D + R, n = 32) or not (group D, n = 23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1–2 h once or twice a week.
Results
Between group D and group D + R, there was no significant difference in baseline data, such as age, Mini‐Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1 mg/day). At 1 year later, however, the Mini‐Mental State Examination score improved only in group D + R from 21.7 to 24.0 (**P < 0.001), whereas that of group D remained at 21.5 with both groups of donepezil 5.0 mg/day.
Conclusion
The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD patients than drug only therapy at 1 year. Geriatr Gerontol Int 2016; 16: 200–204.</description><subject>Aged</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - rehabilitation</subject><subject>Alzheimer's disease</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>cognitive function</subject><subject>cognitive rehabilitation</subject><subject>Cognitive Therapy</subject><subject>Combined Modality Therapy</subject><subject>dementia</subject><subject>donepezil</subject><subject>Humans</subject><subject>Indans - therapeutic use</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Piperidines - therapeutic use</subject><subject>Rehabilitation</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkctu2zAQRYkiRfNoF_2BQEAXzUYJx3yZy8RoXANGC_S9Iyhq5DCRREWU0jpfX9pOvegm3HCAey5nOJeQt0DPIZ2L1cqfw4QL8YIcAecqp0Lzg23NcxBTeUiOY7ylFJQGeEUOJ0IKKRk_ImYWmsK3dvChzQpssfJDFqrMhVXrB_-AWY83tvC1H3ZMV48xK0OLHT76OqtCn13WjzfoG-zfJ8VHtBGzLtHYDvE1eVnZOuKbp_uEfL_-8G32MV9-ni9ml8vcC6Ail4JNiwqZLCmVzmos6WZGcJRNgaErHdeOi0qCLawQ6Fipi1JKPnUThRLYCTnbvdv14X7EOJjGR4d1bVsMYzSgQWvJGefPo0pSTYErldB3_6G3Yezb9JFEpb2C4nJDnT5RY9FgabreN7Zfm39bTsDFDvjta1zvdaBmE59J8ZltfGY-X2yL5Mh3Dh8H_LN32P7OpIZKmJ-f5mb59Yf4pa6-GM7-ArV6m1c</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Matsuzono, Kosuke</creator><creator>Hishikawa, Nozomi</creator><creator>Takao, Yoshiki</creator><creator>Wakutani, Yosuke</creator><creator>Yamashita, Toru</creator><creator>Deguchi, Kentaro</creator><creator>Abe, Koji</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201602</creationdate><title>Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients</title><author>Matsuzono, Kosuke ; Hishikawa, Nozomi ; Takao, Yoshiki ; Wakutani, Yosuke ; Yamashita, Toru ; Deguchi, Kentaro ; Abe, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i5105-6538bfe36d006ca9ed025651c03813ecdc49c45f61aba55ec3d9bd6648c27e613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - rehabilitation</topic><topic>Alzheimer's disease</topic><topic>Cholinesterase Inhibitors - therapeutic use</topic><topic>cognitive function</topic><topic>cognitive rehabilitation</topic><topic>Cognitive Therapy</topic><topic>Combined Modality Therapy</topic><topic>dementia</topic><topic>donepezil</topic><topic>Humans</topic><topic>Indans - therapeutic use</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Piperidines - therapeutic use</topic><topic>Rehabilitation</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuzono, Kosuke</creatorcontrib><creatorcontrib>Hishikawa, Nozomi</creatorcontrib><creatorcontrib>Takao, Yoshiki</creatorcontrib><creatorcontrib>Wakutani, Yosuke</creatorcontrib><creatorcontrib>Yamashita, Toru</creatorcontrib><creatorcontrib>Deguchi, Kentaro</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuzono, Kosuke</au><au>Hishikawa, Nozomi</au><au>Takao, Yoshiki</au><au>Wakutani, Yosuke</au><au>Yamashita, Toru</au><au>Deguchi, Kentaro</au><au>Abe, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatrics & Gerontology International</addtitle><date>2016-02</date><risdate>2016</risdate><volume>16</volume><issue>2</issue><spage>200</spage><epage>204</epage><pages>200-204</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Objects
Alzheimer's disease (AD) is one of the most important diseases in aging society, and non‐drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add‐on effect of cognitive rehabilitation on AD patients under donepezil treatment.
Methods
We retrospectively analyzed 55 AD patients with a Mini‐Mental State Examination score of 15–25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D + R, n = 32) or not (group D, n = 23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1–2 h once or twice a week.
Results
Between group D and group D + R, there was no significant difference in baseline data, such as age, Mini‐Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1 mg/day). At 1 year later, however, the Mini‐Mental State Examination score improved only in group D + R from 21.7 to 24.0 (**P < 0.001), whereas that of group D remained at 21.5 with both groups of donepezil 5.0 mg/day.
Conclusion
The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD patients than drug only therapy at 1 year. Geriatr Gerontol Int 2016; 16: 200–204.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>25656634</pmid><doi>10.1111/ggi.12455</doi><tpages>5</tpages></addata></record> |
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| ispartof | Geriatrics & gerontology international, 2016-02, Vol.16 (2), p.200-204 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aged Alzheimer Disease - drug therapy Alzheimer Disease - rehabilitation Alzheimer's disease Cholinesterase Inhibitors - therapeutic use cognitive function cognitive rehabilitation Cognitive Therapy Combined Modality Therapy dementia donepezil Humans Indans - therapeutic use NMR Nuclear magnetic resonance Piperidines - therapeutic use Rehabilitation Retrospective Studies Severity of Illness Index Treatment Outcome |
| title | Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients |
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