In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats

Our aim was to test whether the presence of three hydraulic calcium silicate dental cements – MTA Angelus, MTA Fillapex, and Theracal LC – in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper inc...

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Bibliographic Details
Published in:European journal of oral sciences 2016-02, Vol.124 (1), p.75-81
Main Authors: Demirkaya, Kadriye, Can Demirdöğen, Birsen, Öncel Torun, Zeynep, Erdem, Onur, Çetinkaya, Serdar, Akay, Cemal
Format: Article
Language:English
Subjects:
Aluminum - blood
Aluminum Compounds
Animals
Calcium
Dental Cements
Drug Combinations
endodontics
Liver
Male
Materials Testing
mineral trioxide aggregate
MTA Angelus
MTA Fillapex
Oxides
Rats
Rats, Wistar
Root Canal Filling Materials
Silicates
Theracal LC
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Summary:Our aim was to test whether the presence of three hydraulic calcium silicate dental cements – MTA Angelus, MTA Fillapex, and Theracal LC – in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper incisor of each male Wistar albino rat was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex, or Theracal LC were inserted into the depth of the extraction socket and gingival tissue was sutured. The rats were killed 7, 30, or 60 d after the operation. Blood and liver samples were obtained from the rats before they were killed, and the levels of Al were measured by atomic absorption spectrometry. Plasma Al levels were higher in the rats in which the mineral trioxide aggregate (MTA) cements were implanted, especially MTA Angelus and MTA Fillapex, compared with control rats. In liver samples, however, the differences in Al level were not statistically significant. Our results show that Al might have been released into the circulation from the three dental cements tested, especially MTA Angelus and MTA Fillapex. Further research should be carried out on the possible biological effects of Al liberated from dental cements.
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12238