T2 relaxation times are increased in Skeletal muscle of DMD but not BMD patients

ABSTRACT Introduction Exon‐skipping drugs in Duchenne muscular dystrophy (DMD) aim to restore truncated dystrophin expression, which is present in the milder Becker muscular dystrophy (BMD). MRI skeletal muscle T2 relaxation times as a representation of edema/inflammation could be quantitative outco...

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Bibliographic Details
Published in:Muscle & nerve 2016-01, Vol.53 (1), p.38-43
Main Authors: Wokke, Beatrijs H., Van Den Bergen, Janneke C., Hooijmans, Melissa T., Verschuuren, Jan J., Niks, Erik H., Kan, Hermien E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Becker
Child
Duchenne
Edema
Female
Humans
inflammation
Leg - pathology
Magnetic Resonance Imaging
Male
Middle Aged
MRI
Muscle, Skeletal - pathology
Muscular dystrophy
Muscular Dystrophy, Duchenne - pathology
Musculoskeletal system
Relaxation
Young Adult
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Summary:ABSTRACT Introduction Exon‐skipping drugs in Duchenne muscular dystrophy (DMD) aim to restore truncated dystrophin expression, which is present in the milder Becker muscular dystrophy (BMD). MRI skeletal muscle T2 relaxation times as a representation of edema/inflammation could be quantitative outcome parameters for such trials. Methods: We studied T2 relaxation times, adjusted for muscle fat fraction using Dixon MRI, in lower leg muscles of DMD and BMD patients and healthy controls. Results: T2 relaxation times correlated significantly with fat fractions in patients only (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.24679