Cilostazol Improves Developmental Competence of Pig Oocytes by Increasing Intraoocyte Cyclic Adenosine Monophosphate Level and Delaying Meiotic Resumption

Cilostazol (CLZ) is a cyclic adenosine monophosphate (cAMP) modulator that influences the steady state of the meiotic stage. This study was conducted to determine the effects of CLZ treatment during in vitro maturation (IVM) on developmental competence of pig oocytes. Immature oocytes were exposed t...

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Bibliographic Details
Published in:Reproduction in domestic animals 2016-04, Vol.51 (2), p.220-226
Main Authors: Elahi, F, Lee, H, Lee, Y, Park, B, Lee, J, Hyun, S-H, Lee, E
Format: Article
Language:English
Subjects:
Animal reproduction
Animals
Cell division
Cyclic AMP - metabolism
Embryo Culture Techniques - veterinary
Hogs
Meiosis - drug effects
Meiosis - physiology
Oocytes - drug effects
Oocytes - physiology
Phosphodiesterase 3 Inhibitors - pharmacology
Swine - embryology
Tetrazoles - pharmacology
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Summary:Cilostazol (CLZ) is a cyclic adenosine monophosphate (cAMP) modulator that influences the steady state of the meiotic stage. This study was conducted to determine the effects of CLZ treatment during in vitro maturation (IVM) on developmental competence of pig oocytes. Immature oocytes were exposed to 0 (control), 0.5, 2 and 4 μm CLZ during the first 22 h of IVM. Nuclear maturation, intraoocyte glutathione content and embryo cleavage after parthenogenesis (PA) and somatic cell nuclear transfer (SCNT) were not influenced by CLZ at any concentrations. However, 4 μm CLZ significantly (p 
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.12669