Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin

A potential targeting drug delivery system consisting of folate (FA), the targeting molecule, human serum albumin (HSA), the carrier, and mitoxantrone (MTO), the medicine, has been designed. Data obtained by UV absorption, fluorescence, and NMR techniques indicated the formation of ternary complexes...

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Bibliographic Details
Published in:Chinese journal of chemistry 2008-08, Vol.26 (8), p.1385-1389
Main Authors: ZHOU, Qiu-Ju, BI, Ya-Jing, XIANG, Jun-Feng, TANG, Ya-Lin, YANG, Qian-Fan, XU, Guang-Zhi
Format: Article
Language:English
Subjects:
cytotoxicity assay
folate
human serum albumin
mitoxantrone
targeting drug delivery system
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Summary:A potential targeting drug delivery system consisting of folate (FA), the targeting molecule, human serum albumin (HSA), the carrier, and mitoxantrone (MTO), the medicine, has been designed. Data obtained by UV absorption, fluorescence, and NMR techniques indicated the formation of ternary complexes and possible application to building a targeting drug delivery system by using FA, MTO and HSA. Furthermore, cytotoxicity assay indicated that the toxicity of the FA‐HSA‐MTO against PC‐3 cell line was 79.95%, which was much higher than that of free MTO tested in totally the same conditions. About 30% increase of the toxicity should be owed to the targeting effect of FA. Thus, the feasibility and validity of a novel targeting drug delivery system, FA‐HSA‐MTO, was confirmed.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.200890252