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Oral Administration of β-Lactamase Preserves Colonization Resistance of Piperacillin-Treated Mice
We hypothesized that orally administered, recombinant class A β-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral β-lactama...
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| Published in: | The Journal of infectious diseases 2003-11, Vol.188 (10), p.1605-1609 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1609 |
| container_issue | 10 |
| container_start_page | 1605 |
| container_title | The Journal of infectious diseases |
| container_volume | 188 |
| creator | Stiefel, Usha Pultz, Nicole J. Harmoinen, Jaana Koski, Pertti Lindevall, Kai Helfand, Marion S. Donskey, Curtis J. |
| description | We hypothesized that orally administered, recombinant class A β-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral β-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of β-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens |
| doi_str_mv | 10.1086/379153 |
| format | article |
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Subcutaneous piperacillin or piperacillin plus oral β-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of β-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/379153</identifier><identifier>PMID: 14624388</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; beta -Lactamase ; beta-Lactam Resistance - drug effects ; beta-Lactamases - pharmacology ; Biological and medical sciences ; Candida glabrata - genetics ; Candida glabrata - metabolism ; Candidiasis - drug therapy ; Community-Acquired Infections - drug therapy ; Cross Infection - drug therapy ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; DNA, Fungal - chemistry ; DNA, Fungal - genetics ; Dosage ; Drug Synergism ; Enterococcus faecium - genetics ; Enterococcus faecium - metabolism ; Enzymes ; Feces - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gels ; Gram-Positive Bacterial Infections - drug therapy ; Health care administration ; Infectious diseases ; Klebsiella Infections - drug therapy ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - metabolism ; Medical sciences ; Mice ; Microbial colonization ; Microbiology ; Microorganisms ; Oral administration ; Pathogens ; piperacillin ; Piperacillin - pharmacokinetics ; Piperacillin - pharmacology ; Polymerase Chain Reaction</subject><ispartof>The Journal of infectious diseases, 2003-11, Vol.188 (10), p.1605-1609</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Nov 15 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-480e54c4de57e88847ef7306f71009d23f34677831c992f3f245207f01e0a4e03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15353164$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14624388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stiefel, Usha</creatorcontrib><creatorcontrib>Pultz, Nicole J.</creatorcontrib><creatorcontrib>Harmoinen, Jaana</creatorcontrib><creatorcontrib>Koski, Pertti</creatorcontrib><creatorcontrib>Lindevall, Kai</creatorcontrib><creatorcontrib>Helfand, Marion S.</creatorcontrib><creatorcontrib>Donskey, Curtis J.</creatorcontrib><title>Oral Administration of β-Lactamase Preserves Colonization Resistance of Piperacillin-Treated Mice</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We hypothesized that orally administered, recombinant class A β-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral β-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of β-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>beta -Lactamase</subject><subject>beta-Lactam Resistance - drug effects</subject><subject>beta-Lactamases - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Candida glabrata - genetics</subject><subject>Candida glabrata - metabolism</subject><subject>Candidiasis - drug therapy</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>Cross Infection - drug therapy</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Fungal - chemistry</subject><subject>DNA, Fungal - genetics</subject><subject>Dosage</subject><subject>Drug Synergism</subject><subject>Enterococcus faecium - genetics</subject><subject>Enterococcus faecium - metabolism</subject><subject>Enzymes</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gels</subject><subject>Gram-Positive Bacterial Infections - drug therapy</subject><subject>Health care administration</subject><subject>Infectious diseases</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Klebsiella pneumoniae - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial colonization</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Oral administration</subject><subject>Pathogens</subject><subject>piperacillin</subject><subject>Piperacillin - pharmacokinetics</subject><subject>Piperacillin - pharmacology</subject><subject>Polymerase Chain Reaction</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp10d2K1DAUB_AgijuO-gZKFfSuevLRJL1cB3XFWXaVEZa9Cdn0BDK2zZi0oj6WD-Iz2aHDDgjeJBfnd84J_xDymMIrClq-5qqmFb9DFtOpSikpv0sWAIyVVNf1CXmQ8xYABJfqPjmhQjLBtV6Qm4tk2-K06UIf8pDsEGJfRF_8-V2urRtsZzMWlwkzpu-Yi1VsYx9-zewz5qnH9g73HZdhh8m60LahLzcJ7YBNcR4cPiT3vG0zPjrcS_Ll3dvN6qxcX7z_sDpdl05oOpRCA1bCiQYrhVprodArDtIrClA3jHsupFKaU1fXzHPPRMVAeaAIViDwJXk5z92l-G3EPJguZIdta3uMYza0ZgDVNGBJnv8Dt3FM_fQ2wxivqWDAjtNcijkn9GaXQmfTT0PB7CM3c-QTfHqYNt502BzZIeMJvDgAm51tfZoSC_noKl5xKsXkns0ujrv_L3sym20eYrpVHEBVSu53lXN9-hj8cVu36auRiqvKnF1dmzfy6uOGfTo31_wvdvep7Q</recordid><startdate>20031115</startdate><enddate>20031115</enddate><creator>Stiefel, Usha</creator><creator>Pultz, Nicole J.</creator><creator>Harmoinen, Jaana</creator><creator>Koski, Pertti</creator><creator>Lindevall, Kai</creator><creator>Helfand, Marion S.</creator><creator>Donskey, Curtis J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20031115</creationdate><title>Oral Administration of β-Lactamase Preserves Colonization Resistance of Piperacillin-Treated Mice</title><author>Stiefel, Usha ; Pultz, Nicole J. ; Harmoinen, Jaana ; Koski, Pertti ; Lindevall, Kai ; Helfand, Marion S. ; Donskey, Curtis J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-480e54c4de57e88847ef7306f71009d23f34677831c992f3f245207f01e0a4e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>beta -Lactamase</topic><topic>beta-Lactam Resistance - drug effects</topic><topic>beta-Lactamases - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Candida glabrata - genetics</topic><topic>Candida glabrata - metabolism</topic><topic>Candidiasis - drug therapy</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>Cross Infection - drug therapy</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Fungal - chemistry</topic><topic>DNA, Fungal - genetics</topic><topic>Dosage</topic><topic>Drug Synergism</topic><topic>Enterococcus faecium - genetics</topic><topic>Enterococcus faecium - metabolism</topic><topic>Enzymes</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gels</topic><topic>Gram-Positive Bacterial Infections - drug therapy</topic><topic>Health care administration</topic><topic>Infectious diseases</topic><topic>Klebsiella Infections - drug therapy</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Klebsiella pneumoniae - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial colonization</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Oral administration</topic><topic>Pathogens</topic><topic>piperacillin</topic><topic>Piperacillin - pharmacokinetics</topic><topic>Piperacillin - pharmacology</topic><topic>Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stiefel, Usha</creatorcontrib><creatorcontrib>Pultz, Nicole J.</creatorcontrib><creatorcontrib>Harmoinen, Jaana</creatorcontrib><creatorcontrib>Koski, Pertti</creatorcontrib><creatorcontrib>Lindevall, Kai</creatorcontrib><creatorcontrib>Helfand, Marion S.</creatorcontrib><creatorcontrib>Donskey, Curtis J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stiefel, Usha</au><au>Pultz, Nicole J.</au><au>Harmoinen, Jaana</au><au>Koski, Pertti</au><au>Lindevall, Kai</au><au>Helfand, Marion S.</au><au>Donskey, Curtis J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Administration of β-Lactamase Preserves Colonization Resistance of Piperacillin-Treated Mice</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-11-15</date><risdate>2003</risdate><volume>188</volume><issue>10</issue><spage>1605</spage><epage>1609</epage><pages>1605-1609</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We hypothesized that orally administered, recombinant class A β-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. 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| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2003-11, Vol.188 (10), p.1605-1609 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Animals Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibiotics beta -Lactamase beta-Lactam Resistance - drug effects beta-Lactamases - pharmacology Biological and medical sciences Candida glabrata - genetics Candida glabrata - metabolism Candidiasis - drug therapy Community-Acquired Infections - drug therapy Cross Infection - drug therapy DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Fungal - chemistry DNA, Fungal - genetics Dosage Drug Synergism Enterococcus faecium - genetics Enterococcus faecium - metabolism Enzymes Feces - microbiology Female Fundamental and applied biological sciences. Psychology Gels Gram-Positive Bacterial Infections - drug therapy Health care administration Infectious diseases Klebsiella Infections - drug therapy Klebsiella pneumoniae - genetics Klebsiella pneumoniae - metabolism Medical sciences Mice Microbial colonization Microbiology Microorganisms Oral administration Pathogens piperacillin Piperacillin - pharmacokinetics Piperacillin - pharmacology Polymerase Chain Reaction |
| title | Oral Administration of β-Lactamase Preserves Colonization Resistance of Piperacillin-Treated Mice |
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