Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer

The present study was to evaluate the prognostic value of protein expression of Pofut1 and Notch1 signaling in breast cancer. Formalin-fixed paraffin-embedded 314 breast specimens including 174 infiltrating ductal carcinoma(IDC), 50 ductal carcinoma in situ(DCIS) and 90 adjacent normal tissue(ANT) w...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2017-09, Vol.491 (1), p.104-111
Main Authors: Wan, Guoxing, Tian, Lin, Yu, Yuandong, Li, Fang, Wang, Xuanbin, Li, Chen, Deng, Shouheng, Yu, Xiongjie, Cai, Xiaojun, Zuo, Zhigang, Cao, Fengjun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
China - epidemiology
Female
Fucosyltransferases - metabolism
Humans
Middle Aged
Neoplasm Invasiveness
Notch1
Pofut1
Prevalence
Prognosis
Receptor, Notch1 - metabolism
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Slug
Survival Rate
Up-Regulation
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Summary:The present study was to evaluate the prognostic value of protein expression of Pofut1 and Notch1 signaling in breast cancer. Formalin-fixed paraffin-embedded 314 breast specimens including 174 infiltrating ductal carcinoma(IDC), 50 ductal carcinoma in situ(DCIS) and 90 adjacent normal tissue(ANT) were immunohistochemically examined to evaluate the protein expression of Pofut1, activated Notch1(N1IC) and Slug on specimens. Survival analysis was performed by Kaplan-Meier method and Cox's proportional-hazards model. A online database was computationally used to further explore the prognostic role of Pofut1 and Notch1 mRNA expression by Kaplan-Meier Plotter. Pofut1, Slug and N1IC expression were significantly increased in IDC compared to ANT(all p 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2017.07.053