Age-dependent ventricular arrhythmias risk, structural and molecular remodeling in systemic arterial hypertension

•Hypertensive rats present more ventricular arrhythmias than normotensive controls.•In this model, left ventricular hypertrophy appears to have antiarrhythmic effects.•Among the hypertensives, molecular remodeling progresses with advancing age.•Kcnj11 expression was deregulated in early, but not sta...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2017-09, Vol.166, p.48-54
Main Authors: Scridon, Alina, Puertas, Rosa Doñate, Manati, Waheed, Fouilloux-Meugnier, Emmanuelle, Loizon, Emmanuelle, Oréa, Valérie, Chapuis, Bruno, Julien, Claude, Barrès, Christian, Tabib, Alain, Chevalier, Philippe
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - pathology
Animals
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - pathology
Arrhythmias, Cardiac - physiopathology
Gene Expression Regulation
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Hypertrophy, Left Ventricular - metabolism
Hypertrophy, Left Ventricular - pathology
Hypertrophy, Left Ventricular - physiopathology
Left ventricular hypertrophy
Male
Molecular remodeling
Potassium Channels, Inwardly Rectifying - biosynthesis
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Risk Factors
Systemic arterial hypertension
Ventricular arrhythmias
Ventricular Remodeling
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Summary:•Hypertensive rats present more ventricular arrhythmias than normotensive controls.•In this model, left ventricular hypertrophy appears to have antiarrhythmic effects.•Among the hypertensives, molecular remodeling progresses with advancing age.•Kcnj11 expression was deregulated in early, but not stable ventricular hypertrophy.•Myocardial energetic changes could underlie this age-dependent arrhythmogenicity. The left ventricular hypertrophy (LVH)-ventricular arrhythmias relationship associated with arterial hypertension and aging remains controversial. We aimed to assess the age-dependency of ventricular arrhythmias in spontaneously hypertensive rats (SHRs) and the corresponding ventricular structural and molecular remodeling. Ventricular arrhythmias were quantified using 24-h radiotelemetry ECG monitoring in eight SHRs and four Wistar-Kyoto (WKY) rats at 14 (young), 24 (adult), and 48 (aging) weeks of age. Left ventricular histology and mRNA expressions of 89 proarrhythmogenic genes were assessed in six additional groups (n=4 each) of young, adult, and aging SHRs and WKYs. Regardless of their age, SHRs presented more premature ventricular contractions (PVCs) than age-matched WKYs (p
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2017.07.002