An acute oral intoxication with haloperidol decanoate

Haloperidol decanoate is a typical antipsychotic drug used as maintenance therapy for schizophrenia and mood disorders formulated as an ester for intramuscular injection. Cases of oral haloperidol decanoate intoxications have not been described in literature. In this report, we present for the first...

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Bibliographic Details
Published in:The American journal of emergency medicine 2017-09, Vol.35 (9), p.1387.e1-1387.e2
Main Authors: Dekkers, Bart G.J., Eck, Ruben J., ter Maaten, Jan C., Touw, Daniël J.
Format: Article
Language:English
Subjects:
Activated charcoal
Administration, Oral
Antipsychotic
Antipsychotic Agents - poisoning
Antipsychotics
Arrhythmias, Cardiac - chemically induced
Blood plasma concentrations
Body temperature
Case reports
Charcoal
Charcoal - therapeutic use
Drug dosages
ECG
Electrocardiography
Emergency medical care
Fatalities
Female
Haloperidol
Haloperidol - analogs & derivatives
Haloperidol - poisoning
Humans
Hypothermia
Ingestion
Intensive care
Intoxication
Laxatives
Laxatives - therapeutic use
Male
Mental disorders
Mood
Oral haloperidol decanoate intoxication
Patients
Plasma levels
Psychotropic drugs
QTc
Schizophrenia
Schizophrenia - drug therapy
Tremor
Young Adult
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Summary:Haloperidol decanoate is a typical antipsychotic drug used as maintenance therapy for schizophrenia and mood disorders formulated as an ester for intramuscular injection. Cases of oral haloperidol decanoate intoxications have not been described in literature. In this report, we present for the first time a case of an oral ingestion of haloperidol decanoate of a young woman who presented to the emergency department following an intentional oral ingestion of 1 ampoule of haloperidol decanoate 100mg. At presentation, she had a bilateral rest tremor of both hands and mild hypothermia. No other obvious signs of an intoxication were observed. She was treated with a single dose of activated charcoal and laxative and was admitted to the intensive care for rhythm monitoring and observation. During the night the QTc interval increased to 453ms, but stayed within the normal range. Haloperidol plasma levels increased as well, but also stayed within therapeutic ranges. These findings indicate that treatment with oral activated charcoal was sufficient to prevent any serious events.
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2017.07.013