The influence of simulated microgravity on proliferation and apoptosis in U251 glioma cells

Several studies have indicated that microgravity can influence cellular progression, proliferation, and apoptosis in tumor cell lines. In this study, we observed that simulated microgravity inhibited proliferation and induced apoptosis in U251 malignant glioma (U251MG) cells. Furthermore, expression...

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Bibliographic Details
Published in:In vitro cellular & developmental biology. Animal 2017-09, Vol.53 (8), p.744-751
Main Authors: Zhao, Jiao, Ma, He, Wu, Leitao, Cao, Liang, Yang, Qianqian, Dong, Haijun, Wang, Zongren, Ma, Jing, Li, Zhen
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Apoptosis
Apoptosis - genetics
Biomedical and Life Sciences
Brain cancer
Cancer therapies
Cell Biology
Cell Culture
Cell cycle
Cell growth
CELL GROWTH/DIFFERENTIATION/APOPTOSIS
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Cyclin-dependent kinase inhibitor p21
Cyclin-Dependent Kinase Inhibitor p21 - genetics
Developmental Biology
Gene Expression Regulation, Neoplastic
Glioma
Glioma - genetics
Glioma - pathology
Glioma cells
Growth factors
GTP-binding protein
Humans
Insulin
Insulin-Like Growth Factor Binding Protein 2 - genetics
Insulin-like growth factor-binding protein 2
Life Sciences
Microgravity
Proteins
Simulation
Stem Cells
Studies
Tumor cell lines
Tumors
Weightlessness Simulation
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Summary:Several studies have indicated that microgravity can influence cellular progression, proliferation, and apoptosis in tumor cell lines. In this study, we observed that simulated microgravity inhibited proliferation and induced apoptosis in U251 malignant glioma (U251MG) cells. Furthermore, expression of the apoptosis-associated proteins, p21 and insulin-like growth factor binding protein-2 (IGFBP-2), was upregulated and downregulated, respectively, following exposure to simulated microgravity. These findings indicate that simulated microgravity inhibits proliferation while inducing apoptosis of U251MG cells. The associated effects appear to be mediated by inhibition of IGFBP-2 expression and stimulation of p21 expression. This suggests that simulated microgravity might represent a promising method to discover new targets for glioma therapeutic strategy.
ISSN:1071-2690
1543-706X
DOI:10.1007/s11626-017-0178-6