Therapeutic peptides: Historical perspectives, current development trends, and future directions

[Display omitted] Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2018-06, Vol.26 (10), p.2700-2707
Main Authors: Lau, Jolene L., Dunn, Michael K.
Format: Article
Language:English
Subjects:
Clinical development
Drug discovery
Drugs
G protein-coupled receptors
Peptides
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Summary:[Display omitted] Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2017.06.052