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Therapeutic peptides: Historical perspectives, current development trends, and future directions
[Display omitted] Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug...
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| Published in: | Bioorganic & medicinal chemistry 2018-06, Vol.26 (10), p.2700-2707 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c462t-c4f1ad93fd7d73b55af1282ccd11a7a7bd4ef5d5eb7f12ebc53abe3192569bfc3 |
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| cites | cdi_FETCH-LOGICAL-c462t-c4f1ad93fd7d73b55af1282ccd11a7a7bd4ef5d5eb7f12ebc53abe3192569bfc3 |
| container_end_page | 2707 |
| container_issue | 10 |
| container_start_page | 2700 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 26 |
| creator | Lau, Jolene L. Dunn, Michael K. |
| description | [Display omitted]
Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown. |
| doi_str_mv | 10.1016/j.bmc.2017.06.052 |
| format | article |
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Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2017.06.052</identifier><identifier>PMID: 28720325</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Clinical development ; Drug discovery ; Drugs ; G protein-coupled receptors ; Peptides</subject><ispartof>Bioorganic & medicinal chemistry, 2018-06, Vol.26 (10), p.2700-2707</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-c4f1ad93fd7d73b55af1282ccd11a7a7bd4ef5d5eb7f12ebc53abe3192569bfc3</citedby><cites>FETCH-LOGICAL-c462t-c4f1ad93fd7d73b55af1282ccd11a7a7bd4ef5d5eb7f12ebc53abe3192569bfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28720325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, Jolene L.</creatorcontrib><creatorcontrib>Dunn, Michael K.</creatorcontrib><title>Therapeutic peptides: Historical perspectives, current development trends, and future directions</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>[Display omitted]
Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown.</description><subject>Clinical development</subject><subject>Drug discovery</subject><subject>Drugs</subject><subject>G protein-coupled receptors</subject><subject>Peptides</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PxCAURYnROOPoD3BjunRhK9BPdGUm6phM4mZcI4VHZNIvgU7iv5em6tINkPfOvQkHoUuCE4JJcbtP6lYmFJMywUWCc3qEliQrsjhNGTlGS8yKKsYVKxbozLk9xphmjJyiBa1KilOaL9H77gOsGGD0RkYDDN4ocHfRxjjfWyNFE4bWDSC9OYC7ieRoLXQ-UnCAph_a6e3DRIWd6FSkRz9aiJSxU6Tv3Dk60aJxcPFzr9Db0-NuvYm3r88v64dtLLOC-nBqIhRLtSpVmdZ5LjShFZVSESJKUdYqA52rHOoyLKCWeSpqSAmjecFqLdMVup57B9t_juA8b42T0DSig350PJA4WKkYCyiZUWl75yxoPljTCvvFCeaTWL7nQSyfxHJc8CA2ZK5-6se6BfWX-DUZgPsZgPDJgwHLnTTQSZhVcNWbf-q_ATnCi9k</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Lau, Jolene L.</creator><creator>Dunn, Michael K.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Therapeutic peptides: Historical perspectives, current development trends, and future directions</title><author>Lau, Jolene L. ; Dunn, Michael K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-c4f1ad93fd7d73b55af1282ccd11a7a7bd4ef5d5eb7f12ebc53abe3192569bfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Clinical development</topic><topic>Drug discovery</topic><topic>Drugs</topic><topic>G protein-coupled receptors</topic><topic>Peptides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, Jolene L.</creatorcontrib><creatorcontrib>Dunn, Michael K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, Jolene L.</au><au>Dunn, Michael K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic peptides: Historical perspectives, current development trends, and future directions</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>26</volume><issue>10</issue><spage>2700</spage><epage>2707</epage><pages>2700-2707</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>[Display omitted]
Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and other major markets, and peptides continue to enter clinical development at a steady pace. Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. We maintain a comprehensive dataset on peptides that have entered human clinical studies that includes over 150 peptides in active development today. Here we provide an overview of the peptide therapeutic landscape, including historical perspectives, molecular characteristics, regulatory benchmarks, and a therapeutic area breakdown.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28720325</pmid><doi>10.1016/j.bmc.2017.06.052</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2018-06, Vol.26 (10), p.2700-2707 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1920391899 |
| source | Elsevier |
| subjects | Clinical development Drug discovery Drugs G protein-coupled receptors Peptides |
| title | Therapeutic peptides: Historical perspectives, current development trends, and future directions |
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