AHRQ series on complex intervention systematic reviews—paper 3: adapting frameworks to develop protocols

Once a proposed topic has been identified for a systematic review and has undergone a question formulation stage, a protocol must be developed that specifies the scope and research questions in detail and outlines the methodology for conducting the systematic review. Framework modifications are ofte...

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Bibliographic Details
Published in:Journal of clinical epidemiology 2017-10, Vol.90, p.19-27
Main Authors: Butler, Mary, Epstein, Richard A., Totten, Annette, Whitlock, Evelyn P., Ansari, Mohammed T., Damschroder, Laura J., Balk, Ethan, Bass, Eric B., Berkman, Nancy D., Hempel, Susanne, Iyer, Suchitra, Schoelles, Karen, Guise, Jeanne-Marie
Format: Article
Language:English
Subjects:
Analytic frameworks
Complex interventions
Data Interpretation, Statistical
Evidence-Based Medicine
Guidelines as Topic
Humans
Research Design
Review Literature as Topic
Systematic reviews
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Summary:Once a proposed topic has been identified for a systematic review and has undergone a question formulation stage, a protocol must be developed that specifies the scope and research questions in detail and outlines the methodology for conducting the systematic review. Framework modifications are often needed to accommodate increased complexity. We describe and give examples of adaptations and alternatives to traditional analytic frameworks. This article identifies and describes elements of frameworks and how they can be adapted to inform the protocol and conduct of systematic reviews of complex interventions. Modifications may be needed to adapt the population, intervention, comparators, and outcomes normally used in protocol development to successfully describe complex interventions; in some instances, alternative frameworks may be better suited. Possible approaches to analytic frameworks for complex interventions that illustrate causal and associative linkages are outlined, including time elements, which systematic reviews of complex interventions may need to address. The need for and specifics of the accommodations vary with details of a specific systematic review. This in turn helps determine whether traditional frameworks are sufficient, can be refined, or if alternate frameworks must be adopted.
ISSN:0895-4356
1878-5921
DOI:10.1016/j.jclinepi.2017.06.013