How to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach

Purpose To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. Procedures In this prospective clinical trial, 20 children and young adults (11–30 years old,...

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Bibliographic Details
Published in:Molecular imaging and biology 2018-04, Vol.20 (2), p.324-335
Main Authors: Muehe, Anne M., Theruvath, Ashok J., Lai, Lillian, Aghighi, Maryam, Quon, Andrew, Holdsworth, Samantha J., Wang, Jia, Luna-Fineman, Sandra, Marina, Neyssa, Advani, Ranjana, Rosenberg, Jarrett, Daldrup-Link, Heike E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Cancer
Chelates
Child
Children
Computed tomography
Data processing
Diagnostic systems
Exposure
Fluorine isotopes
Gadolinium
Gadolinium - chemistry
Glucose
Humans
Image acquisition
Image enhancement
Imaging
Intravenous administration
Iron
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung nodules
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Multimodal Imaging
Neoplasm Staging
Neoplasms - diagnostic imaging
Neoplasms - pathology
Nodules
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography
Radiation
Radiation effects
Radiology
Research Article
Solid tumors
Thigh
Tomography
Tomography, X-Ray Computed
Tumors
Young Adult
Young adults
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Summary:Purpose To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. Procedures In this prospective clinical trial, 20 children and young adults (11–30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ 18 F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [ 18 F]FDG (2–3 MBq/kg). Time needed for patient preparation, PET/MR image acquisition, and data processing was compared before ( n  = 5) and after ( n  = 15) time-saving interventions, using a Wilcoxon test. The ferumoxytol-enhanced PET/MR images were compared with clinical standard staging tests regarding radiation exposure and tumor staging results, using Fisher’s exact tests. Results Tailored workflows significantly reduced scan times from 36 to 24 min for head to mid thigh scans ( p  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-017-1105-7