Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals

Bone morphogenetic proteins (BMPs), BMP receptors (BMPRs), and endogenous BMP antagonists have been found to be critically important for the development of the central nervous system (CNS) and peripheral organs in mammals. There is also increasing evidence that this system has significant activity i...

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Bibliographic Details
Published in:Brain research 2003-12, Vol.994 (1), p.81-90
Main Authors: Chen, Hui-Ling, Lein, Pamela J., Wang, Jia-Yi, Gash, Don, Hoffer, Barry J., Chiang, Yung-Hsiao
Format: Article
Language:English
Subjects:
6-hydroxydopamine
Aging
Aging - drug effects
Aging - metabolism
Animals
Biological and medical sciences
Bone morphogenetic proteins
Bone Morphogenetic Proteins - biosynthesis
Bone Morphogenetic Proteins - genetics
Brain - drug effects
Brain - physiology
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
Male
Oxidopamine - toxicity
Rats
Rats, Inbred F344
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Substantia nigra
Vertebrates: nervous system and sense organs
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Summary:Bone morphogenetic proteins (BMPs), BMP receptors (BMPRs), and endogenous BMP antagonists have been found to be critically important for the development of the central nervous system (CNS) and peripheral organs in mammals. There is also increasing evidence that this system has significant activity in the adult CNS. Accordingly, we studied the regional distribution of endogenous BMP ligand proteins, receptors, and antagonists during aging and after lesion of the midbrain dopamine pathways produced by 6-hydroxydopamine (6-OHDA). We found that there were only small changes in the levels of these molecules as a function of age. Interestingly, levels of BMP 7 and noggin, a BMP antagonist, were uniquely elevated in substantia nigra. Moreover, after lesions of the midbrain dopamine system by 6-hydroxydopamine, there was a marked reduction in levels of all BMP ligands, receptors and antagonists bilaterally in both substantia nigra and hippocampus. There were also differential changes in BMP ligands, receptors, and antagonists in the cortex and striatum after such lesions. Taken together, our results indicate significant expression of BMP-related molecules in the adult and aging brain, and suggest a dynamic and differential regulation of these molecules after perturbations.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2003.09.020