A Study of the Therapeutic Effects of Resveratrol on Blunt Chest Trauma-Induced Acute Lung Injury in Rats and the Potential Role of Endocan as a Biomarker of Inflammation

The present study focused on the therapeutic effects of resveratrol in a rat model of blunt chest trauma-induced acute lung injury and the potential role of endocan as a biomarker of inflammation. They were randomly divided into the following four groups ( n  = 7 in each group): control group (no tr...

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Bibliographic Details
Published in:Inflammation 2017-10, Vol.40 (5), p.1803-1810
Main Authors: Torun, Aysun Caglar, Tutuncu, Serife, Ustun, Burcu, Akdemir, Hızır Ufuk
Format: Article
Language:English
Subjects:
Acute Lung Injury - drug therapy
Acute Lung Injury - etiology
Acute Lung Injury - pathology
Animals
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biomarkers
Biomedical and Life Sciences
Biomedicine
Chest
Immunology
Inflammation
Inflammation - diagnosis
Internal Medicine
Lungs
Original Article
Pathology
Pharmacology/Toxicology
Proteoglycans - blood
Rats
Resveratrol
Rheumatology
Rodents
Serum levels
Stilbenes - therapeutic use
Thoracic Injuries
Trauma
Ventilators
Wounds, Nonpenetrating
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Summary:The present study focused on the therapeutic effects of resveratrol in a rat model of blunt chest trauma-induced acute lung injury and the potential role of endocan as a biomarker of inflammation. They were randomly divided into the following four groups ( n  = 7 in each group): control group (no treatment or trauma); trauma group (trauma-induced group); resveratrol group (resveratrol [0.3 mg/kg] administered via the i.p. route group); and resveratrol + trauma group (resveratrol [0.3 mg/kg] administered via the i.p. route 1 h prior to the induction of trauma At the end of the 24 h, all the experimental rats were sacrificed. Lung lobe and blood samples were collected for biochemical, histopathological, and immunohistochemical investigations. Serum endocan levels were found to be significantly higher in the travma, resveratrol, and resveratrol + trauma groups than in the control group ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-017-0624-3