Impact of albumin based approaches in nanomedicine: Imaging, targeting and drug delivery

• Published in: Advances in colloid and interface science 2017-08, Vol.246, p.13-39
• Main Authors: Bhushan, Bharat, Khanadeev, Vitaly, Khlebtsov, Boris, Khlebtsov, Nikolai, Gopinath, P.
• Format: Article
• Language: English
• Subjects: Albumin nanoparticles; Biomedical applications; Cancer imaging; Cancer therapy; Drug delivery
• ISSN: 0001-8686; 1873-3727
• DOI: 10.1016/j.cis.2017.06.012

A major challenge in the field of nanomedicine is to transform laboratory innovations into commercially successful clinical products. In this campaign, a variety of nanoenabled approaches have been designed and investigated for their role in biomedical applications. The advantages associated with the unique structure of albumin imparts it with the ability to interact with variety of molecules, while the functional groups present on their surface provide base for large number of modifications making it as an ideal nanocarrier system. So far, a variety of albumin based nanoenabled approaches have been intensively exploited for effective diagnosis and personalized medicine, among them some have successfully completed their journey from lab bench to marketed products. This review focuses on the recent most promising advancement in the field of albumin based nanoenabled approaches for various biomedical applications and their potential use in cancer diagnosis and therapy. [Display omitted] •Recent advancement in the field of albumin-based nanoenabled approaches is reviewed.•Insight on various modes of their preparation and their therapeutic applications•Highlighted the various biomedical applications of albumin-based nanomaterials