In vitro Antiproliferative and Antibacterial Activities of Essential Oils from Four Species of Guatteria

The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2017-10, Vol.14 (10), p.n/a
Main Authors: Santos, Anderson R., Benghi, Thalita Gilda S., Nepel, Angelita, Marques, Francisco A., Lobão, Adriana Q., Duarte, Marta Cristina T., Ruiz, Ana Lúcia T. G., Carvalho, João E., Maia, Beatriz H. L. N. S.
Format: Article
Language:English
Subjects:
Active control
Annonaceae
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antiproliferative activity
Antiproliferatives
Bacteria - drug effects
Caryophyllene
Caryophyllene oxide
Cell Line, Tumor
Cell Proliferation - drug effects
Doxorubicin
Drug Screening Assays, Antitumor
Essential oils
Guatteria
Guatteria - chemistry
Humans
Iron constituents
Microbial Sensitivity Tests
Molecular Structure
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
Ovarian cancer
Rhodococcus
Rhodococcus equi
Selectivity
Sesquiterpenes
Spathulenol
Species
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 – 40.29%) and caryophyllene oxide (7.74 – 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the EOs showed strong selectivity (1.1 – 4.1 μg/ml) against the tumor cell line OVCAR‐03 (ovarian cancer), i.e., more active than the positive control doxorubicin (11.7 μg/ml). All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 0.062 – 0.25 mg/ml) against strains of Rhodococcus equi.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201700097