In vitro Antiproliferative and Antibacterial Activities of Essential Oils from Four Species of Guatteria

• Published in: Chemistry & biodiversity 2017-10, Vol.14 (10), p.n/a
• Main Authors: Santos, Anderson R., Benghi, Thalita Gilda S., Nepel, Angelita, Marques, Francisco A., Lobão, Adriana Q., Duarte, Marta Cristina T., Ruiz, Ana Lúcia T. G., Carvalho, João E., Maia, Beatriz H. L. N. S.
• Format: Article
• Language: English
• Subjects: Active control; Annonaceae; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antiproliferative activity; Antiproliferatives; Bacteria - drug effects; Caryophyllene; Caryophyllene oxide; Cell Line, Tumor; Cell Proliferation - drug effects; Doxorubicin; Drug Screening Assays, Antitumor; Essential oils; Guatteria; Guatteria - chemistry; Humans; Iron constituents; Microbial Sensitivity Tests; Molecular Structure; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; Ovarian cancer; Rhodococcus; Rhodococcus equi; Selectivity; Sesquiterpenes; Spathulenol; Species
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.201700097

The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 – 40.29%) and caryophyllene oxide (7.74 – 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the EOs showed strong selectivity (1.1 – 4.1 μg/ml) against the tumor cell line OVCAR‐03 (ovarian cancer), i.e., more active than the positive control doxorubicin (11.7 μg/ml). All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 0.062 – 0.25 mg/ml) against strains of Rhodococcus equi.