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Anomalously high excretion of Pu in urine following inhalation of plutonium nitrate?

A study of the biokinetics of inhaled plutonium nitrate in two volunteers has been carried out. Low doses (approximately 80 microSv) were achievable because tracers of high isotopic purity were used: 237Pu (measurable by X ray spectrometry) and 244Pu (measurable by accelerator mass spectrometry). Lu...

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Published in:	Radiation protection dosimetry 2003, Vol.105 (1-4), p.321-324
Main Authors:	ETHERINGTON, G, STRADLING, G. N, HODGSON, A, FIFIELD, L. K
Format:	Article
Language:	English
Subjects:	Administration, Inhalation Biological and medical sciences Humans Incidental Findings Liver - metabolism Lung - metabolism Male Medical sciences Nitrates - administration & dosage Nitrates - blood Nitrates - pharmacokinetics Nitrates - urine Plutonium - administration & dosage Plutonium - blood Plutonium - pharmacokinetics Plutonium - urine Radiation Dosage Radiometry - methods
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container_title	Radiation protection dosimetry
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creator	ETHERINGTON, G STRADLING, G. N HODGSON, A FIFIELD, L. K
description	A study of the biokinetics of inhaled plutonium nitrate in two volunteers has been carried out. Low doses (approximately 80 microSv) were achievable because tracers of high isotopic purity were used: 237Pu (measurable by X ray spectrometry) and 244Pu (measurable by accelerator mass spectrometry). Lung retention, amount in blood, uptake to the liver and skeleton, and urinary and faecal excretion were measured. The measured urinary excretion rates are about a factor of three higher than those predicted from urine excretion data measured following intravenous injection of plutonium to the same volunteers. If similar biokinetic behaviour occurs in workers exposed to plutonium nitrate, intakes by inhalation and corresponding committed doses assessed by urine bioassay could be consistently overestimated by a similar factor.
doi_str_mv	10.1093/oxfordjournals.rpd.a006248
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source	Oxford Journals Online
subjects	Administration, Inhalation Biological and medical sciences Humans Incidental Findings Liver - metabolism Lung - metabolism Male Medical sciences Nitrates - administration & dosage Nitrates - blood Nitrates - pharmacokinetics Nitrates - urine Plutonium - administration & dosage Plutonium - blood Plutonium - pharmacokinetics Plutonium - urine Radiation Dosage Radiometry - methods
title	Anomalously high excretion of Pu in urine following inhalation of plutonium nitrate?
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