Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene

Background Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism. Methods Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86...

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Bibliographic Details
Published in:American journal of industrial medicine 2004-02, Vol.45 (2), p.186-193
Main Authors: Mas, S., Casterad, X., Laso, N., Lafuente, M.J., Panades, R., Calleja, A., Hernandez, S., Turuguet, D., Deulofeu, R., Ballesta, A., Ascaso, C., Lafuente, A.
Format: Article
Language:English
Subjects:
a1-antitrypsin
Alleles
alpha 1 antitrypsin
alpha 1-Antitrypsin - genetics
alpha 1-Antitrypsin Deficiency - genetics
asbestos
Asbestos - metabolism
Asbestos - toxicity
asbestosis
Asbestosis - diagnosis
Asbestosis - epidemiology
Asbestosis - genetics
Biological and medical sciences
biomarkers
Biomarkers - blood
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
Female
gene polymorphism
Genotype
Humans
hydroxyproline
Hydroxyproline - blood
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Male
Medical sciences
Middle Aged
Occupational Diseases - epidemiology
Occupational Diseases - etiology
occupational exposure
Occupational Exposure - adverse effects
Occupational Exposure - statistics & numerical data
polymorphism
Polymorphism, Genetic
Risk Factors
Spain
Toxicology
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Summary:Background Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism. Methods Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86), and non‐exposed population (non‐exposed controls, NEC, n = 122) were studied. The concentration of free OHP in whole blood was measured following the Pico‐Tag procedure. Results Concentration of OHP in blood was significantly different in the three groups studied (P 
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.10350