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Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene
Background Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism. Methods Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86...
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| Published in: | American journal of industrial medicine 2004-02, Vol.45 (2), p.186-193 |
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| container_end_page | 193 |
| container_issue | 2 |
| container_start_page | 186 |
| container_title | American journal of industrial medicine |
| container_volume | 45 |
| creator | Mas, S. Casterad, X. Laso, N. Lafuente, M.J. Panades, R. Calleja, A. Hernandez, S. Turuguet, D. Deulofeu, R. Ballesta, A. Ascaso, C. Lafuente, A. |
| description | Background
Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism.
Methods
Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86), and non‐exposed population (non‐exposed controls, NEC, n = 122) were studied. The concentration of free OHP in whole blood was measured following the Pico‐Tag procedure.
Results
Concentration of OHP in blood was significantly different in the three groups studied (P |
| doi_str_mv | 10.1002/ajim.10350 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19216403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19216403</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4260-3108cdc6593c5f432e61c1140e94fed857357a860599993e15b3d21df893b4413</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EotvChR-AfIFDpYAd2_ngtlpBKSplJUAgLpbjTBoXJw62V938MP4f3g_oDV_GmnlmRvO-CD2j5BUlJH-tbs2QfkyQB2hBSV1mJC_5Q7RIgWZMVMUJOg3hlhBKecEfoxPKS14RXi_Q75UbNYzRq2jciF2H-7n1bjtP3lkzAjYjbqxz7Ru8xI1x1t0YrSwelP8Jfld1Wm-mfXdKw3ZyYeMBR4dVaCBEF7AaW2xiwB7sngu9mfCdiT1emx_76tp8xpOz8-D81Jsw7ObGHrCyU68ymphoop-nkPI3MMIT9KhTNsDTYzxDX9-9_bJ6n119urhcLa8yzfOCZIySSre6EDXTouMsh4LqpAGBmnfQVqJkolRVQUSdHgMqGtbmtO2qmjWcU3aGXh7mJjV-bdI1cjBBg7VqBLcJktY5LThhCTw_gNq7EDx0cvImaTRLSuTOJLkzSe5NSvDz49RNM0B7jx5dScCLI6BCErvzatQm3HOC87zOReLogbszFub_rJTLD5cf_y7PDj0mRNj-60l2yqJkpZDfri_ktSjrdf2dyoL9AVjTu0M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19216403</pqid></control><display><type>article</type><title>Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene</title><source>Wiley</source><creator>Mas, S. ; Casterad, X. ; Laso, N. ; Lafuente, M.J. ; Panades, R. ; Calleja, A. ; Hernandez, S. ; Turuguet, D. ; Deulofeu, R. ; Ballesta, A. ; Ascaso, C. ; Lafuente, A.</creator><creatorcontrib>Mas, S. ; Casterad, X. ; Laso, N. ; Lafuente, M.J. ; Panades, R. ; Calleja, A. ; Hernandez, S. ; Turuguet, D. ; Deulofeu, R. ; Ballesta, A. ; Ascaso, C. ; Lafuente, A.</creatorcontrib><description>Background
Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism.
Methods
Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86), and non‐exposed population (non‐exposed controls, NEC, n = 122) were studied. The concentration of free OHP in whole blood was measured following the Pico‐Tag procedure.
Results
Concentration of OHP in blood was significantly different in the three groups studied (P < 0.001), being higher in cases (19.8 ± 14.7 μmol/L) than in EC (16 ± 12.4) and NEC (13.5 ± 6.7). When all individuals were grouped and stratified by the Pi*S and Pi*Z polymorphisms in the alpha‐1‐antitrypsin gene, the highest OHP levels were detected in the Pi*S homozygotes, one of the asbestosis‐at risk‐genotypes (Pi*S homozygotes, x = 24.5 ± 11.7; Pi*S heterozygotes, x = 16.6 ± 10.0; wild type, wt, x = 15.9 ± 11.8).
Conclusions
Blood OHP concentration could be used for monitoring human exposure to asbestos, either as a marker for occupational monitoring or as an additional clinical parameter in diagnostic exploration of asbestosis. Am. J. Ind. Med. 45:186–193, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.10350</identifier><identifier>PMID: 14748049</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>a1-antitrypsin ; Alleles ; alpha 1 antitrypsin ; alpha 1-Antitrypsin - genetics ; alpha 1-Antitrypsin Deficiency - genetics ; asbestos ; Asbestos - metabolism ; Asbestos - toxicity ; asbestosis ; Asbestosis - diagnosis ; Asbestosis - epidemiology ; Asbestosis - genetics ; Biological and medical sciences ; biomarkers ; Biomarkers - blood ; Case-Control Studies ; Chemical and industrial products toxicology. Toxic occupational diseases ; Female ; gene polymorphism ; Genotype ; Humans ; hydroxyproline ; Hydroxyproline - blood ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Male ; Medical sciences ; Middle Aged ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - statistics & numerical data ; polymorphism ; Polymorphism, Genetic ; Risk Factors ; Spain ; Toxicology</subject><ispartof>American journal of industrial medicine, 2004-02, Vol.45 (2), p.186-193</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4260-3108cdc6593c5f432e61c1140e94fed857357a860599993e15b3d21df893b4413</citedby><cites>FETCH-LOGICAL-c4260-3108cdc6593c5f432e61c1140e94fed857357a860599993e15b3d21df893b4413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15442925$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14748049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mas, S.</creatorcontrib><creatorcontrib>Casterad, X.</creatorcontrib><creatorcontrib>Laso, N.</creatorcontrib><creatorcontrib>Lafuente, M.J.</creatorcontrib><creatorcontrib>Panades, R.</creatorcontrib><creatorcontrib>Calleja, A.</creatorcontrib><creatorcontrib>Hernandez, S.</creatorcontrib><creatorcontrib>Turuguet, D.</creatorcontrib><creatorcontrib>Deulofeu, R.</creatorcontrib><creatorcontrib>Ballesta, A.</creatorcontrib><creatorcontrib>Ascaso, C.</creatorcontrib><creatorcontrib>Lafuente, A.</creatorcontrib><title>Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism.
Methods
Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86), and non‐exposed population (non‐exposed controls, NEC, n = 122) were studied. The concentration of free OHP in whole blood was measured following the Pico‐Tag procedure.
Results
Concentration of OHP in blood was significantly different in the three groups studied (P < 0.001), being higher in cases (19.8 ± 14.7 μmol/L) than in EC (16 ± 12.4) and NEC (13.5 ± 6.7). When all individuals were grouped and stratified by the Pi*S and Pi*Z polymorphisms in the alpha‐1‐antitrypsin gene, the highest OHP levels were detected in the Pi*S homozygotes, one of the asbestosis‐at risk‐genotypes (Pi*S homozygotes, x = 24.5 ± 11.7; Pi*S heterozygotes, x = 16.6 ± 10.0; wild type, wt, x = 15.9 ± 11.8).
Conclusions
Blood OHP concentration could be used for monitoring human exposure to asbestos, either as a marker for occupational monitoring or as an additional clinical parameter in diagnostic exploration of asbestosis. Am. J. Ind. Med. 45:186–193, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>a1-antitrypsin</subject><subject>Alleles</subject><subject>alpha 1 antitrypsin</subject><subject>alpha 1-Antitrypsin - genetics</subject><subject>alpha 1-Antitrypsin Deficiency - genetics</subject><subject>asbestos</subject><subject>Asbestos - metabolism</subject><subject>Asbestos - toxicity</subject><subject>asbestosis</subject><subject>Asbestosis - diagnosis</subject><subject>Asbestosis - epidemiology</subject><subject>Asbestosis - genetics</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Female</subject><subject>gene polymorphism</subject><subject>Genotype</subject><subject>Humans</subject><subject>hydroxyproline</subject><subject>Hydroxyproline - blood</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Spain</subject><subject>Toxicology</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi0EotvChR-AfIFDpYAd2_ngtlpBKSplJUAgLpbjTBoXJw62V938MP4f3g_oDV_GmnlmRvO-CD2j5BUlJH-tbs2QfkyQB2hBSV1mJC_5Q7RIgWZMVMUJOg3hlhBKecEfoxPKS14RXi_Q75UbNYzRq2jciF2H-7n1bjtP3lkzAjYjbqxz7Ru8xI1x1t0YrSwelP8Jfld1Wm-mfXdKw3ZyYeMBR4dVaCBEF7AaW2xiwB7sngu9mfCdiT1emx_76tp8xpOz8-D81Jsw7ObGHrCyU68ymphoop-nkPI3MMIT9KhTNsDTYzxDX9-9_bJ6n119urhcLa8yzfOCZIySSre6EDXTouMsh4LqpAGBmnfQVqJkolRVQUSdHgMqGtbmtO2qmjWcU3aGXh7mJjV-bdI1cjBBg7VqBLcJktY5LThhCTw_gNq7EDx0cvImaTRLSuTOJLkzSe5NSvDz49RNM0B7jx5dScCLI6BCErvzatQm3HOC87zOReLogbszFub_rJTLD5cf_y7PDj0mRNj-60l2yqJkpZDfri_ktSjrdf2dyoL9AVjTu0M</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Mas, S.</creator><creator>Casterad, X.</creator><creator>Laso, N.</creator><creator>Lafuente, M.J.</creator><creator>Panades, R.</creator><creator>Calleja, A.</creator><creator>Hernandez, S.</creator><creator>Turuguet, D.</creator><creator>Deulofeu, R.</creator><creator>Ballesta, A.</creator><creator>Ascaso, C.</creator><creator>Lafuente, A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200402</creationdate><title>Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene</title><author>Mas, S. ; Casterad, X. ; Laso, N. ; Lafuente, M.J. ; Panades, R. ; Calleja, A. ; Hernandez, S. ; Turuguet, D. ; Deulofeu, R. ; Ballesta, A. ; Ascaso, C. ; Lafuente, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4260-3108cdc6593c5f432e61c1140e94fed857357a860599993e15b3d21df893b4413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>a1-antitrypsin</topic><topic>Alleles</topic><topic>alpha 1 antitrypsin</topic><topic>alpha 1-Antitrypsin - genetics</topic><topic>alpha 1-Antitrypsin Deficiency - genetics</topic><topic>asbestos</topic><topic>Asbestos - metabolism</topic><topic>Asbestos - toxicity</topic><topic>asbestosis</topic><topic>Asbestosis - diagnosis</topic><topic>Asbestosis - epidemiology</topic><topic>Asbestosis - genetics</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Female</topic><topic>gene polymorphism</topic><topic>Genotype</topic><topic>Humans</topic><topic>hydroxyproline</topic><topic>Hydroxyproline - blood</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - statistics & numerical data</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Spain</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mas, S.</creatorcontrib><creatorcontrib>Casterad, X.</creatorcontrib><creatorcontrib>Laso, N.</creatorcontrib><creatorcontrib>Lafuente, M.J.</creatorcontrib><creatorcontrib>Panades, R.</creatorcontrib><creatorcontrib>Calleja, A.</creatorcontrib><creatorcontrib>Hernandez, S.</creatorcontrib><creatorcontrib>Turuguet, D.</creatorcontrib><creatorcontrib>Deulofeu, R.</creatorcontrib><creatorcontrib>Ballesta, A.</creatorcontrib><creatorcontrib>Ascaso, C.</creatorcontrib><creatorcontrib>Lafuente, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mas, S.</au><au>Casterad, X.</au><au>Laso, N.</au><au>Lafuente, M.J.</au><au>Panades, R.</au><au>Calleja, A.</au><au>Hernandez, S.</au><au>Turuguet, D.</au><au>Deulofeu, R.</au><au>Ballesta, A.</au><au>Ascaso, C.</au><au>Lafuente, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2004-02</date><risdate>2004</risdate><volume>45</volume><issue>2</issue><spage>186</spage><epage>193</epage><pages>186-193</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
Hydroxyproline (OHP) is one of the most abundant amino acids in collagen and, in general, it provides a good measure of overall collagen catabolism.
Methods
Asbestos workers suffering from asbestosis (cases n = 85); asbestos exposed workers without asbestosis (exposed controls, EC, n = 86), and non‐exposed population (non‐exposed controls, NEC, n = 122) were studied. The concentration of free OHP in whole blood was measured following the Pico‐Tag procedure.
Results
Concentration of OHP in blood was significantly different in the three groups studied (P < 0.001), being higher in cases (19.8 ± 14.7 μmol/L) than in EC (16 ± 12.4) and NEC (13.5 ± 6.7). When all individuals were grouped and stratified by the Pi*S and Pi*Z polymorphisms in the alpha‐1‐antitrypsin gene, the highest OHP levels were detected in the Pi*S homozygotes, one of the asbestosis‐at risk‐genotypes (Pi*S homozygotes, x = 24.5 ± 11.7; Pi*S heterozygotes, x = 16.6 ± 10.0; wild type, wt, x = 15.9 ± 11.8).
Conclusions
Blood OHP concentration could be used for monitoring human exposure to asbestos, either as a marker for occupational monitoring or as an additional clinical parameter in diagnostic exploration of asbestosis. Am. J. Ind. Med. 45:186–193, 2004. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14748049</pmid><doi>10.1002/ajim.10350</doi><tpages>8</tpages></addata></record> |
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| subjects | a1-antitrypsin Alleles alpha 1 antitrypsin alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin Deficiency - genetics asbestos Asbestos - metabolism Asbestos - toxicity asbestosis Asbestosis - diagnosis Asbestosis - epidemiology Asbestosis - genetics Biological and medical sciences biomarkers Biomarkers - blood Case-Control Studies Chemical and industrial products toxicology. Toxic occupational diseases Female gene polymorphism Genotype Humans hydroxyproline Hydroxyproline - blood Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Male Medical sciences Middle Aged Occupational Diseases - epidemiology Occupational Diseases - etiology occupational exposure Occupational Exposure - adverse effects Occupational Exposure - statistics & numerical data polymorphism Polymorphism, Genetic Risk Factors Spain Toxicology |
| title | Concentration of hydroxyproline in blood: A biological marker in occupational exposure to asbestos and its relationship with PiZ and PiS polymorphism in the alpha-1 antitrypsin gene |
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