Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis

Summary Background There is an increasing need for allergen inhalation systems to perform basic clinical research and test anti‐allergic drugs under well‐controlled conditions. This requires stability of environmental conditions like temperature and humidity, as well as allergen concentration and re...

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Bibliographic Details
Published in:Clinical and experimental allergy 2003-12, Vol.33 (12), p.1667-1674
Main Authors: Krug, N., Loedding, H., Hohlfeld, J. M., Larbig, M., Buckendahl, A., Badorrek, P., Geldmacher, H., Behnke, W., Dunkhorst, W., Windt, H., Luettig, B., Koch, W.
Format: Article
Language:English
Subjects:
Adult
allergen challenge
Allergens - analysis
Allergic diseases
Biological and medical sciences
Bronchial Hyperreactivity
Environmental Exposure
environmental exposure unit
Female
grass pollen
Humans
Immunopathology
Male
Medical sciences
Nasal Provocation Tests - instrumentation
Nasal Provocation Tests - methods
Poaceae
Pollen
Respiratory and ent allergic diseases
Rhinitis, Allergic, Seasonal - immunology
seasonal allergic rhinitis
Time Factors
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Summary:Summary Background There is an increasing need for allergen inhalation systems to perform basic clinical research and test anti‐allergic drugs under well‐controlled conditions. This requires stability of environmental conditions like temperature and humidity, as well as allergen concentration and reproducible induction of allergic symptoms. Objective The aim of this study was to validate an environmental exposure unit for controlled human pollen inhalation studies in participants with seasonal allergic rhinitis. Methods Temperature, relative humidity, and air flow rate were kept constant with an air conditioning system. Pollen atmosphere was generated using a specially designed feeding system and monitored online by laser counter and offline using rotating rod samplers. Efficacy (total nasal symptom score, nasal air flow rate, nasal secretion) and safety (lung function) parameters were evaluated at different pollen concentrations and repeated allergen challenges. Results Temperature, humidity, and air flow rate in the environmental exposure unit remained constant within a range of
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.2003.01810.x