d- chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose

d- chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Effects of gold-thioglucose (GT...

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Bibliographic Details
Published in:Brain research 2003-12, Vol.993 (1), p.172-176
Main Authors: Isoda, Fumiko, Shiry, Laura, Abergel, Jeffrey, Allan, Geoffry, Mobbs, Charles
Format: Article
Language:English
Subjects:
Agouti-Related Protein
Analysis of Variance
Animals
Antirheumatic Agents - toxicity
Aurothioglucose - toxicity
Biological and medical sciences
Body Weight - drug effects
Drug Synergism
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus
Hypothalamus - drug effects
Hypothalamus - injuries
Hypothalamus - pathology
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Inositol - pharmacology
Insulin resistance
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred Strains
Obesity
Polycystic ovarian syndrome
Pro-Opiomelanocortin - genetics
Pro-Opiomelanocortin - metabolism
Proteins - metabolism
RNA, Messenger - metabolism
Vertebrates: endocrinology
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Summary:d- chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Effects of gold-thioglucose (GTG) to produce hypothalamic lesions and subsequent obesity are insulin-dependent, suggesting that responses to GTG may be a marker of hypothalamic sensitivity to insulin. To assess these hypotheses, the present study assessed if DCI would enhance the ability of a subthreshhold dose of GTG to produce hypothalamic lesions and subsequent obesity. At the subthreshhold dose used (0.4 mg/kg i.p.), injection of GTG produced no subsequent effect on body weight compared to saline; similarly, at the dose of DCI used (10 mg/kg/day in drinking water), DCI produced no effect on body weight. In contrast, when given to mice exposed to DCI, this dose of GTG produced significant increase in body weight and evidence of an enhanced medial arcuate hypothalamic lesion.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2003.09.008