SCCA2-like serpins mediate genetic predisposition to skin tumors

Reasons for early onset skin cancer are poorly understood. Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2003-04, Vol.63 (8), p.1871-1875
Main Authors: GARIBOLDI, Manuela, PEISSEL, Bernard, MAURICHI, Andrea, BARTOLI, Cesare, CATALTEPE, Sule, SILVERMAN, Gary A, PILOTTI, Silvana, HAYASHIZAKI, Yoshihide, OKAZAKI, Yasushi, DRAGANI, Tommaso A, FABBRI, Alessandra, SARAN, Anna, ZAFFARONI, Daniela, FALVELLA, F. Stefania, SPINOLA, Monica, TANUMA, Jun-Ichi, PAZZAGLIA, Simonetta, MANCUSO, Maria Teresa
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Antigens, Neoplasm - biosynthesis
Antigens, Neoplasm - genetics
Biological and medical sciences
Carcinoma, Squamous Cell - chemically induced
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Cell Division - genetics
Dermatology
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Male
Medical sciences
Mice
Mice, Nude
Middle Aged
Oligonucleotide Array Sequence Analysis
Serpins - biosynthesis
Serpins - genetics
Skin Neoplasms - chemically induced
Skin Neoplasms - genetics
Skin Neoplasms - metabolism
Tetradecanoylphorbol Acetate
Transfection
Tumors of the skin and soft tissue. Premalignant lesions
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reasons for early onset skin cancer are poorly understood. Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-R mice, which is resistant. A human skin squamous cell carcinoma cell line (NCI-H520) transfected with mouse Scca2 or a related gene, Scca2-rs1, both expressed in the skin, showed significantly increased tumor growth as compared with controls when injected in nude mice. Immunohistochemical analysis of samples from two independent series of Italian and Korean patients with squamous cell carcinoma of the skin indicated a significant association between SCCA2 protein expression and younger age at tumor onset. These findings provide evidence that SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans.
ISSN:0008-5472
1538-7445