A comprehensive review of agrimoniin

Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin––dimeric ellagitannin––is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982...

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Published in:Annals of the New York Academy of Sciences 2017-08, Vol.1401 (1), p.166-180
Main Authors: Grochowski, Daniel M., Skalicka‐Woźniak, Krystyna, Orhan, Ilkay Erdogan, Xiao, Jianbo, Locatelli, Marcello, Piwowarski, Jakub P., Granica, Sebastian, Tomczyk, Michał
Format: Article
Language:English
Subjects:
agrimoniin
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biocompatibility
biological activity
Biological effects
chemistry
ellagitannin
Food
Humans
Hydrolyzable Tannins - isolation & purification
hyphated techniques
In vitro methods and tests
Inflammation
Intestinal microflora
Medicinal plants
metabolism
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plants (botany)
Polyphenols
Rosaceae
Strawberries
Tannins
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Summary:Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin––dimeric ellagitannin––is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures. It is also present in commonly consumed food products, such as strawberries and raspberries. It is metabolized by human gut microbiota into a series of low‐molecular‐weight urolithins with proven anti‐inflammatory and anticancer in vivo and in vitro bioactivities. The compound has received widespread interest owing to some interesting biological effects and therapeutic activities, which we elaborate in the present review. Additionally, we present an overview of the techniques used for the analysis, isolation, and separation of agrimoniin from the practical perspective.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.13421