Lifetime Psychiatric Disorders: a Comparision Study Between Offspring of Parents With Bipolar Disorder Type-I Versus the Offspring of Community Controls Parents

• Published in: Revista colombiana de psiquiatría 2017-07, Vol.46 (3), p.129-139
• Main Authors: Palacio-Ortiz, Juan David, Peña-Quintero, Cristian Esteban, Gómez-Valero, María Alejandra, Bustamante-Gómez, Paula Andrea, Arroyave-Sierra, Pilar Helena, Vargas-Upeguí, Cristian David, López-Jaramillo, Carlos
• Format: Article
• Language: Spanish
• Subjects: Adolescent; Adult; Bipolar Disorder - epidemiology; Child; Child of Impaired Parents - psychology; Cross-Sectional Studies; Female; Humans; Interviews as Topic; Male; Mental Disorders - epidemiology; Mental Disorders - physiopathology; Middle Aged; Prevalence; Psychiatric Status Rating Scales; Young Adult
• ISSN: 0034-7450
• DOI: 10.1016/j.rcp.2016.06.007

Literature reports show that Bipolar Offspring (BO) present with a wide range of psychiatric disorders. Comparison between BO and Control Parent Offspring (CPO) may help to identify which psychopathological findings are specific to this high-risk group. To compare the psychopathological characteristics between a group of BO type-I and a group of CPO, by identifying the presence of psychiatric disorders according the DSM-IV-TR. A descriptive-correlational, cross-sectional and comparative study was conducted with 127 offspring of parents with bipolar disorder type-I from the multimodal intervention program (PRISMA) and with 150 CPO between 6 and 30 years of age. Subjects were evaluated with validated diagnostic interviews (K-SADS-PL and DIGS). The BO group showed higher frequencies for bipolar disorder (Prevalence Ratio [PR]=17.70; 95% confidence interval [CI]; 1.02 - 306.83), bipolar disorder not otherwise specified (PR=23.07, 95% CI; 2.8 - 189.0, P=.0001), disorders due to psychoactive substance use (PR=9.52, 95% CI; 2.93 -30.90), oppositional defiant disorder (PR=4.10, 95% CI; 1.70 -9.89), posttraumatic stress disorder (PR=3.90, 95% CI 1.30 -11.66), disorder due to alcohol use (PR=3.84, 95% CI; 1.28 -11.48), attention deficit/hyperactivity disorder (PR=2.26, 95% CI; 1.37 -3.75), and major depressive disorder (PR=2.25, 95% CI; 1.13 -4.50). Statistically significant differences were also found in the CGAS and GAF functional scales, with lower scores for the BO group. These findings confirm previous literature reports showing that BO have higher rates of affective and non-affective psychiatric disorders than control subjects, and also a lower level of global functioning.