Long-acting water-stable organosilane agent and its sustained effect on reducing microbial load in an intensive care unit

Contaminated hospital surfaces contribute significantly to the transmission of health care-associated infections. Although disinfectants reduce bioburden by up to 99%, bacterial growth can rebound within hours to precleaning levels. We tested the effectiveness of an innovative, long-acting water-sta...

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Published in:American journal of infection control 2017-11, Vol.45 (11), p.1214-1217
Main Authors: Fitton, Katie, Barber, Kimberly R., Karamon, Alison, Zuehlke, Nate, Atwell, Sara, Enright, Susan
Format: Article
Language:English
Subjects:
Bacterial Load
Colony Count, Microbial
Cross Infection - prevention & control
Disinfectants - therapeutic use
Double-Blind Method
Environmental services
Environmental stewardship
HAI
High-touch surfaces
Humans
Intensive Care Units - standards
Staphylococcus - growth & development
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container_issue 11
container_start_page 1214
container_title American journal of infection control
container_volume 45
creator Fitton, Katie
Barber, Kimberly R.
Karamon, Alison
Zuehlke, Nate
Atwell, Sara
Enright, Susan
description Contaminated hospital surfaces contribute significantly to the transmission of health care-associated infections. Although disinfectants reduce bioburden by up to 99%, bacterial growth can rebound within hours to precleaning levels. We tested the effectiveness of an innovative, long-acting water-stable organosilane (WSO) to achieve sustained decreases in bioburden on hard surfaces. A 5-month prospective, randomized, double-blind controlled study was performed. Eighteen intensive care unit rooms were randomly divided into placebo or treatment groups. Hard surfaces in all rooms were cleaned using the same protocol, except the placebo surfaces were cleaned with an inert saline solution and the treatment surfaces were treated with the WSO. Binomial regression with repeated measures were used to assess mean reductions in total bioburden as measured by colony forming units. The placebo resulted in average reductions in total colony forming units of 35% to 40% (relative risk reduction [RRR], 0.65; P 
doi_str_mv 10.1016/j.ajic.2017.06.014
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subjects Bacterial Load
Colony Count, Microbial
Cross Infection - prevention & control
Disinfectants - therapeutic use
Double-Blind Method
Environmental services
Environmental stewardship
HAI
High-touch surfaces
Humans
Intensive Care Units - standards
Staphylococcus - growth & development
title Long-acting water-stable organosilane agent and its sustained effect on reducing microbial load in an intensive care unit
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