The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system

Many Gram-negative commensal and pathogenic bacteria use a type II secretion system (T2SS) to transport proteins out of the cell. These exported proteins or substrates play a major role in toxin delivery, maintaining biofilms, replication in the host and subversion of host immune responses to infect...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Proteins and proteomics 2017-10, Vol.1865 (10), p.1255-1266
Main Authors: Gu, Shuang, Shevchik, Vladimir E., Shaw, Rosie, Pickersgill, Richard W., Garnett, James A.
Format: Article
Language:English
Subjects:
Biofilms
Dynamics
Gram negative bacteria
Humans
Intrinsic disorder
Pathogen
Protein Transport - physiology
Proteins - metabolism
Secretin
Secretion
Type II secretion system
Type II Secretion Systems - metabolism
Type III secretion system
Type IV pilus
Virulence
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Summary:Many Gram-negative commensal and pathogenic bacteria use a type II secretion system (T2SS) to transport proteins out of the cell. These exported proteins or substrates play a major role in toxin delivery, maintaining biofilms, replication in the host and subversion of host immune responses to infection. We review the current structural and functional work on this system and argue that intrinsically disordered regions and protein dynamics are central for assembly, exo-protein recognition, and secretion competence of the T2SS. The central role of intrinsic disorder-order transitions in these processes may be a particular feature of type II secretion.
ISSN:1570-9639
1878-1454
DOI:10.1016/j.bbapap.2017.07.006