Polyamines: therapeutic perspectives in oxidative stress and inflammatory diseases

• Published in: Amino acids 2017-09, Vol.49 (9), p.1457-1468
• Main Authors: Hussain, Tarique, Tan, Bie, Ren, Wenkai, Rahu, Najma, Dad, Rahim, Kalhoro, Dildar Hussain, Yin, Yulong
• Format: Article
• Language: English
• Subjects: Aliphatic compounds; Analytical Chemistry; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antioxidants - metabolism; Antioxidants - therapeutic use; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; Cancer; Catabolism; Differentiation; Drug development; Hepatitis - drug therapy; Hepatitis - metabolism; Hepatitis - pathology; Humans; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Inflammatory response; Life Sciences; Life span; Liver; Liver cancer; Liver diseases; Metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Nervous System Diseases - drug therapy; Nervous System Diseases - metabolism; Nervous System Diseases - pathology; Neurobiology; Neurological diseases; Oxidative stress; Oxidative Stress - drug effects; Polyamines; Polyamines - metabolism; Polyamines - therapeutic use; Proteomics; Renal failure; Renal Insufficiency - metabolism; Renal Insufficiency - pathology; Renal Insufficiency - prevention & control; Review Article; Stroke; Stroke - metabolism; Stroke - pathology; Stroke - prevention & control; Supplements
• ISSN: 0939-4451; 1438-2199
• DOI: 10.1007/s00726-017-2447-9

Polyamines are naturally occurring aliphatic compounds, particularly essential elements for biological functions. These compounds play a central role in regulating molecular pathways which are responsible for cellular proliferation, growth, and differentiation. Importantly, excessive polyamine catabolism can lead to a prominent source of oxidative stress which increases inflammatory response and thought to be involved in several diseases including stroke, renal failure, neurological disease, liver disease, and even cancer. Moreover, polyamine supplementation increases life span in model organisms and may encounter oxidative stress via exerting its potential anti-oxidant and anti-inflammatory properties. The revealed literature indicates that an emerging role of polyamine biosynthetic pathway could be a novel target for drug development against inflammatory diseases. In this review, we expand the knowledge on the metabolism of polyamines, and its anti-oxidant and anti-inflammatory activities which might have future implications against inflammatory diseases in humans and animals.