Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Alginate is a copolymer of β-d-mannuronate and α-l-guluronate, which are present in the cell wall of brown algae. The hypocholesterolemic and hypolipidemic activities of alginate and its derivative, which is prepared by a reaction with octadecylamine, were compared in rats fed diets containing chole...

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Published in:International journal of biological macromolecules 2017-12, Vol.105 (Pt 1), p.620-624
Main Authors: Marounek, Milan, Volek, Zdeněk, Skřivanová, Eva, Taubner, Tomáš, Pebriansyah, Akhir, Dušková, Dagmar
Format: Article
Language:English
Subjects:
Alginate
Alginates - chemistry
Alginates - pharmacology
Amidated alginate
Amides - chemistry
Animals
Anticholesteremic Agents - chemistry
Anticholesteremic Agents - pharmacology
Body Weight - drug effects
Cholesterol
Eating - drug effects
Female
Glucuronic Acid - chemistry
Glucuronic Acid - pharmacology
Hexuronic Acids - chemistry
Hexuronic Acids - pharmacology
Lipid Metabolism - drug effects
Liver - drug effects
Liver - metabolism
Rat
Rats
Rats, Wistar
Serum lipids
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Summary:Alginate is a copolymer of β-d-mannuronate and α-l-guluronate, which are present in the cell wall of brown algae. The hypocholesterolemic and hypolipidemic activities of alginate and its derivative, which is prepared by a reaction with octadecylamine, were compared in rats fed diets containing cholesterol and palm fat at 10 and 50g/kg, respectively. Amidated alginate at 20g/kg significantly decreased serum cholesterol from 2.93 to 2.00μmol/mL, serum triacylglycerols from 1.66 to 0.92μmol/mL, hepatic cholesterol from 17.5 to 5.9μmol/g, and total hepatic lipids from 67.4 to 51.7mg/g. Alginate at 20g/kg significantly reduced hepatic cholesterol to 13.1μmol/g, but did not influence serum cholesterol, triacylglycerols, and total hepatic lipids. Amidated alginate significantly increased the faecal concentrations of neutral sterols from 98.7 to 122.4μmol/g DM, but decreased faecal concentration of bile acids from 19.4 to 14.0μmol/g DM. In samples of intestinal contents, taurine-conjugated bile acids dominated glycine conjugates. The supplementation of diets with cholesterol significantly increased the expression of hepatic cholesterol 7α-hydroxylase, especially in rats that received cholesterol without alginate or amidated alginate. In conclusion, amidated alginate is an effective hypocholesterolemic agent that is more efficient than its parent polysaccharide.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2017.07.077