IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

Objective The aim of this study was to evaluate the association of IL17A G197A polymorphism and serum levels with oral lichen planus (OLP) susceptibility and clinical presentation. Subjects and Methods Eighty‐three individuals diagnosed with OLP and 99 healthy controls (C) were consecutively recruit...

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Bibliographic Details
Published in:Oral diseases 2018-04, Vol.24 (3), p.377-383
Main Authors: Gueiros, LA, Arão, T, Souza, T, Vieira, CL, Gomez, RS, Almeida, OP, Lodi, G, Leão, JC
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Dentistry
disease susceptibility
Female
Gene polymorphism
genetic polymorphism
Genetic Predisposition to Disease - genetics
Genotyping
Helper cells
Humans
Interleukin 1
interleukin 17
Interleukin-17 - blood
Interleukin-17 - genetics
Lichen planus
Lichen Planus, Oral - blood
Lichen Planus, Oral - genetics
Lymphocytes T
Male
Middle Aged
Mucosa
Oral diseases
oral lichen planus
Polymorphism, Single Nucleotide
Serum levels
Young Adult
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Summary:Objective The aim of this study was to evaluate the association of IL17A G197A polymorphism and serum levels with oral lichen planus (OLP) susceptibility and clinical presentation. Subjects and Methods Eighty‐three individuals diagnosed with OLP and 99 healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL17A (G197A) genotyping. Blood samples of 42 OLP individuals and 23 healthy controls were collected for evaluation of IL17A serum levels. Results IL17A G197A genotypes were associated with an increased chance of having OLP (GA/AA × GG, OR = 3.44, 95% CI = 1.87–6.33, p 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12718