Metabolic bone disease in preterm infants: Relationship between radiologic grading in the wrist and serum biochemical markers

• Published in: Diagnostic and interventional imaging 2017-11, Vol.98 (11), p.785-791
• Main Authors: You, S.K., Lee, J.E., Lee, S.M., Cho, H.-H.
• Format: Article
• Language: English
• Subjects: Alkaline phosphatase; Alkaline Phosphatase - blood; Biomarkers - blood; Bone Diseases, Metabolic - diagnosis; Female; Humans; Infant, Newborn; Infant, Premature; Male; Metabolic bone disease; Phosphorus - blood; Preterm infant; Radiographs; Radiography; Radius - diagnostic imaging; Retrospective Studies; Severity of Illness Index; Ulna - diagnostic imaging; Wrist
• ISSN: 2211-5684; 2211-5684
• DOI: 10.1016/j.diii.2017.06.008

To assess the relationship between radiographic findings of metabolic bone disease (MBD) and serum biochemical markers in preterm infants. A total of 159 preterm infants were included in this study. Two readers reviewed the wrist radiography for grading according to MBD severity. We recorded the levels of alkaline phosphatase (ALP) and phosphorous (P) immediately after birth, on the same day of the first wrist radiography (ALP-s, P-s), the highest/lowest ALP/P levels before the first wrist radiography (ALP-hb/P-lb) and during follow-up (ALP-h/P-l). For analysis, the patients were first subdivided into 4 groups according to MBD severity, and were then divided into 2 groups according to MBD presence or absence. Of the 159 patients, 94, 39, 19, and 7 infants were classified into grades 0,1, 2, and 3. Analysis according to severity showed that ALP-s, ALP-hb, and ALP-h differed between grades 0–1 and 2–3 (all P