A variant on chromosome 2p13.3 is associated with atopic dermatitis in Chinese Han population

Multi-ancestry genome-wide association study (GWAS) has recently identified 11 new susceptibility loci for Atopic dermatitis (AD). The replication of these new susceptibility loci in different populations should not be ignored. To examine whether these 11 new identified susceptibility loci are also...

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Bibliographic Details
Published in:Gene 2017-09, Vol.628, p.281-285
Main Authors: Cai, Xin-Ying, Zheng, Xiao-Dong, Fang, Ling, Zhou, Fu-Sheng, Sheng, Yu-Jun, Wu, Yan-Yan, Yu, Chong-Xian, Zhu, Jun, Xiao, Feng-Li
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Antigens, CD - genetics
Atopic dermatitis
Case-Control Studies
Child
Child, Preschool
China
Chromosomes, Human, Pair 2
Computational Biology - methods
Dermatitis, Atopic - genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Infant
Infant, Newborn
Lectins, C-Type - genetics
Male
Mannose-Binding Lectins - genetics
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
rs112111458
Single-nucleotide polymorphism
Susceptibility loci
Young Adult
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Summary:Multi-ancestry genome-wide association study (GWAS) has recently identified 11 new susceptibility loci for Atopic dermatitis (AD). The replication of these new susceptibility loci in different populations should not be ignored. To examine whether these 11 new identified susceptibility loci are also associated with AD in the Chinese Han population. These 11 variants were imputed using our genome-wide array dataset. The selected SNPs with suggestive signals were genotyped in a large-scale replication study with a total of 4619 cases and 10,789 controls using the Sequenom Massarray system. Association analyses were performed using PLINK 1.07 software. Results were combined across our previous AD-GWAS stage and the replication stage by meta-analysis. Bioinformatic analysis was done to predict the possible causal gene. Of the 11 SNPs investigated, four SNPs showed suggestive association (P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2017.07.059