Adverse bone effects of medications used to treat non-skeletal disorders

There is a growing list of medications used to treat non-skeletal disorders that cause bone loss and/or increase fracture risk. This review discusses glucocorticoids, drugs that reduce sex steroids, antidiabetic agents, acid-reducing drugs, selective serotonin reuptake inhibitors, and heparin. A num...

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Bibliographic Details
Published in:Osteoporosis international 2017-10, Vol.28 (10), p.2741-2746
Main Author: Watts, N. B.
Format: Article
Language:English
Subjects:
Antacids - adverse effects
Antidepressants
Antidiabetics
Bone loss
Diabetes mellitus
Drugs
Endocrinology
Fractures
Glucocorticoids
Glucocorticoids - adverse effects
Heparin
Hormone Antagonists - adverse effects
Humans
Hypoglycemic Agents - adverse effects
Medicine
Medicine & Public Health
Orthopedics
Osteoporosis - chemically induced
Osteoporotic Fractures - chemically induced
Review
Rheumatology
Serotonin uptake inhibitors
Serotonin Uptake Inhibitors - adverse effects
Steroid hormones
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Summary:There is a growing list of medications used to treat non-skeletal disorders that cause bone loss and/or increase fracture risk. This review discusses glucocorticoids, drugs that reduce sex steroids, antidiabetic agents, acid-reducing drugs, selective serotonin reuptake inhibitors, and heparin. A number of drugs are known to cause bone loss, increase fracture risk, or both. These drugs should be used in the lowest dose necessary to achieve the desired benefit and for the shortest time necessary, but in many cases, long-term treatment is required. Effective countermeasures are available for some.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-017-4171-4