Association of UBASH3A gene polymorphism and atopic dermatitis in the Chinese Han population

Genome-wide association studies have revealed a large number of genetic-risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases share susceptibility loci. Recent evidence has demonstrated that UBASH3A...

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Bibliographic Details
Published in:Genes and immunity 2017-09, Vol.18 (3), p.158-162
Main Authors: Li, Y, Cheng, H, Xiao, F-L, Liang, B, Zhou, F-s, Li, P, Zheng, X-d, Sun, L-d, Yang, S, Zhang, X-j
Format: Article
Language:English
Subjects:
45
631/208/205
631/250/38
Adaptor Proteins, Signal Transducing - genetics
Adult
Atopic dermatitis
Autoimmune diseases
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Cancer Research
Care and treatment
Case-Control Studies
Child
Child, Preschool
China
Dermatitis
Dermatitis, Atopic - genetics
Diagnosis
Eczema
Female
Gene Expression
Gene mapping
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genome-wide association studies
Genomes
Genotyping
Human Genetics
Humans
Immunology
Infant
Male
Medical research
Medicine, Experimental
original-article
Polymorphism
Polymorphism, Single Nucleotide
Population studies
Replication
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
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Summary:Genome-wide association studies have revealed a large number of genetic-risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases share susceptibility loci. Recent evidence has demonstrated that UBASH3A gene was associated with multiple autoimmune diseases. The aim of this study was to explore the association between UBASH3A single-nucleotide polymorphisms (SNPs) and atopic dermatitis (AD) in a Chinese Han population. In total, three UBASH3A SNPs (rs11203203, rs3788013 and rs1893592) were genotyped using TaqMan genotyping assays in a Chinese Han population (1012 cases and 1362 controls). Among these SNPs, we selected the SNP rs1893592 with association values of P
ISSN:1466-4879
1476-5470
DOI:10.1038/gene.2017.15