Effectiveness of Adjuvant Chemotherapy After Radical Cystectomy for Locally Advanced and/or Pelvic Lymph Node–Positive Muscle-invasive Urothelial Carcinoma of the Bladder: A Propensity Score–Weighted Competing Risks Analysis

• Published in: European urology focus 2018-03, Vol.4 (2), p.252-259
• Main Authors: Vetterlein, Malte W, Seisen, Thomas, May, Matthias, Nuhn, Philipp, Gierth, Michael, Mayr, Roman, Fritsche, Hans-Martin, Burger, Maximilian, Novotny, Vladimir, Froehner, Michael, Wirth, Manfred P, Protzel, Chris, Hakenberg, Oliver W, Roghmann, Florian, Palisaar, Rein-Jüri, Noldus, Joachim, Pycha, Armin, Bastian, Patrick J, Trinh, Quoc-Dien, Xylinas, Evanguelos, Shariat, Shahrokh F, Rink, Michael, Chun, Felix K.-H, Dahlem, Roland, Fisch, Margit, Aziz, Atiqullah
• Format: Article
• Language: English
• Subjects: Adjuvant chemotherapy; Aged; Aged, 80 and over; Carcinoma, Transitional Cell - drug therapy; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - surgery; Chemotherapy, Adjuvant - adverse effects; Cisplatin - therapeutic use; Cystectomy; Cystectomy - methods; Cytotoxins - therapeutic use; Female; Humans; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Male; Middle Aged; Neoplasm Recurrence, Local - drug therapy; Propensity score; Prospective Studies; Retrospective Studies; Risk Assessment; Survival; Survival Analysis; Treatment Outcome; Urinary Bladder - pathology; Urinary Bladder - surgery; Urinary bladder neoplasms; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; Urology
• ISSN: 2405-4569; 2405-4569
• DOI: 10.1016/j.euf.2016.07.001

Abstract Background The benefit of adjuvant chemotherapy (AC) for muscle-invasive urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC) is controversial. Objective To assess the effectiveness of AC after RC for muscle-invasive UCB in contemporary European routine practice. Design, setting, and participants By using a prospectively collected European multicenter database, we compared survival outcomes between patients who received AC versus observation after RC for locally advanced (pT3/T4) and/or pelvic lymph node–positive (pN+) muscle-invasive UCB in 2011. Intervention AC versus observation after RC. Outcome measurements and statistical analysis Inverse probability of treatment weighting (IPTW)–adjusted Cox regression and competing risks analyses were performed to compare overall survival (OS) as well as cancer-specific and other-cause mortality between patients who received AC versus observation. Results and limitations Overall, 224 patients who received AC ( n = 84) versus observation ( n = 140) were included. The rate of 3-yr OS in patients who received AC versus observation was 62.1% versus 40.9%, respectively ( p = 0.014). In IPTW-adjusted Cox regression analysis, AC versus observation was associated with an OS benefit (hazard ratio: 0.47; 95% confidence interval [CI]: 0.25–0.86; p = 0.014). In IPTW-adjusted competing risks analysis, AC versus observation was associated with a decreased risk of cancer-specific mortality (subhazard ratio: 0.51; 95% CI: 0.26–0.98; p = 0.044) without any increased risk of other-cause mortality (subhazard ratio: 0.48; 95% CI: 0.14–1.60; p = 0.233). Limitations include the relatively small sample size as well as the potential presence of unmeasured confounders related to the observational study design. Conclusions We found that AC versus observation was associated with a survival benefit after RC in patients with pT3/T4 and/or pN+ UCB. These results should encourage physicians to deliver AC and researchers to pursue prospective or large observational investigations. Patient summary Overall survival and cancer-specific survival benefit was found in patients who received adjuvant chemotherapy relative to observation after radical cystectomy for locally advanced and/or pelvic lymph node–positive bladder cancer.