Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women

Plasma concentrations of vitamin D metabolites can be inversely associated with depressive symptoms. However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin...

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Published in:Journal of psychiatric research 2017-12, Vol.95, p.1-8
Main Authors: Cunha Figueiredo, Amanda C., Trujillo, Janet, Freitas-Vilela, Ana Amélia, Franco-Sena, Ana Beatriz, Rebelo, Fernanda, Cunha, Geraldo Marcelo, de Castro, Maria Beatriz Trindade, Farnum, Amanda, Mokhtar, Rana R., Holick, Michael F., Kac, Gilberto
Format: Article
Language:English
Subjects:
Adult
Brazil
Brazil - epidemiology
Calcitriol - blood
Depression
Depression - blood
Depression - epidemiology
Depression - physiopathology
Female
Humans
Mental health
Micronutrients
Pregnancy
Pregnancy - blood
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Pregnancy Complications - physiopathology
Prospective Studies
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult
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container_title Journal of psychiatric research
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creator Cunha Figueiredo, Amanda C.
Trujillo, Janet
Freitas-Vilela, Ana Amélia
Franco-Sena, Ana Beatriz
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Cunha, Geraldo Marcelo
de Castro, Maria Beatriz Trindade
Farnum, Amanda
Mokhtar, Rana R.
Holick, Michael F.
Kac, Gilberto
description Plasma concentrations of vitamin D metabolites can be inversely associated with depressive symptoms. However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin D [1,25(OH)2D] with the occurrence of depressive symptoms throughout pregnancy. A prospective cohort of 179 women was followed at 5th-13th, 20th-26th and 30th-36th gestational weeks. At each trimester of pregnancy, the plasma concentrations of 25(OH)D and 1,25(OH)2D were analyzed by liquid chromatography tandem mass spectroscopy. Vitamin D status was categorized according to the Endocrine Society Practice Guidelines and the Institute of Medicine. Depressive symptoms were measured at each trimester using the Edinburgh Postnatal Depressive Scale (cutoff ≥13). Statistical analyses included random intercept logistic regression models for longitudinal analyses. In the first trimester, the prevalence of 25(OH)D 
doi_str_mv 10.1016/j.jpsychires.2017.07.009
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However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin D [1,25(OH)2D] with the occurrence of depressive symptoms throughout pregnancy. A prospective cohort of 179 women was followed at 5th-13th, 20th-26th and 30th-36th gestational weeks. At each trimester of pregnancy, the plasma concentrations of 25(OH)D and 1,25(OH)2D were analyzed by liquid chromatography tandem mass spectroscopy. Vitamin D status was categorized according to the Endocrine Society Practice Guidelines and the Institute of Medicine. Depressive symptoms were measured at each trimester using the Edinburgh Postnatal Depressive Scale (cutoff ≥13). Statistical analyses included random intercept logistic regression models for longitudinal analyses. In the first trimester, the prevalence of 25(OH)D &lt;75, &lt;50 and &lt;30 nmol/L were 69.3%, 14.0% and 1.7%, respectively. Prevalence of depressive symptoms were 20.1%, 14.7% and 7.8% for the first, second and third trimesters, respectively. The probability of occurrence of depressive symptoms decreased throughout pregnancy (p-value = 0.005). Women with higher concentrations of 25(OH)D in the first trimester presented a lower odds ratio (OR) for the development of depressive symptoms during pregnancy (OR = 0.98; 95%CI: 0.96 to 0.99, p-value = 0.047) in the adjusted model. In conclusion, there was a higher prevalence of vitamin D inadequacy and depressive symptoms during the first trimester. 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subjects Adult
Brazil
Brazil - epidemiology
Calcitriol - blood
Depression
Depression - blood
Depression - epidemiology
Depression - physiopathology
Female
Humans
Mental health
Micronutrients
Pregnancy
Pregnancy - blood
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Pregnancy Complications - physiopathology
Prospective Studies
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult
title Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women
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