Continuous Glucose Monitoring Detected Hypoglycaemia in the Treating to Target in Type 2 Diabetes Trial (4-T)

Highlights • Reported frequencies of self-reported hypoglycaemia in clinical trials may significantly underestimate interstitial hypoglycaemic events detected by continuous glucose monitoring. • This highlights risk of minimising important adverse effects of glucose lowering therapies in the light o...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-09, Vol.131, p.161-168
Main Authors: Levy, JC, Davies, MJ, Holman, RR
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Blood Glucose Self-Monitoring - methods
Clinical trials
Continuous glucose monitoring
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Endocrinology & Metabolism
Female
Humans
Hypoglycaemia
Hypoglycemia - diagnosis
Hypoglycemia - drug therapy
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Insulin therapy
Male
Middle Aged
Type 2 diabetes
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Description
Summary:Highlights • Reported frequencies of self-reported hypoglycaemia in clinical trials may significantly underestimate interstitial hypoglycaemic events detected by continuous glucose monitoring. • This highlights risk of minimising important adverse effects of glucose lowering therapies in the light of associations between hypoglycaemia and major cardiovascular events.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.01.022