Effectiveness of octreotide in a case of refractory sulfonylurea-induced hypoglycemia

The use of sulfonylurea medications in the treatment of type 2 diabetes mellitus is common. Patients who present to the Emergency Department after ingestion of excessive amounts of suflonylurea medications often have hypoglycemia refractory to dextrose administration. Standard care includes the admi...

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Bibliographic Details
Published in:The Journal of emergency medicine 2003-10, Vol.25 (3), p.283-287
Main Authors: Green, Robert S, Palatnick, Wes
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Drug intoxications. Doping
Female
Glyburide - administration & dosage
Glyburide - poisoning
Humans
hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - drug therapy
Medical sciences
octreotide
Octreotide - therapeutic use
oral hypoglycemics
Pharmacology. Drug treatments
Suicide, Attempted
sulfonylurea
sulfonylureas
toxicology
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Summary:The use of sulfonylurea medications in the treatment of type 2 diabetes mellitus is common. Patients who present to the Emergency Department after ingestion of excessive amounts of suflonylurea medications often have hypoglycemia refractory to dextrose administration. Standard care includes the administration of dextrose, glucagon, and diazoxide. Recently, the use of octreotide has been described as an alternative treatment in these patients. We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide. Octreotide administration rapidly reversed hypoglycemia allowing patient stabilization and eventual discharge without any significant adverse events.
ISSN:0736-4679
2352-5029
DOI:10.1016/S0736-4679(03)00204-X