Serial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation and temozolomide

The immune system plays a significant role in cancer prevention and outcome. In high grade astrocytomas (HGA), severe lymphopenia is associated with shortened survival due to tumor progression. This study was performed to quantify serial changes in lymphocyte subsets in HGA following standard radiat...

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Bibliographic Details
Published in:Journal of neuro-oncology 2017-11, Vol.135 (2), p.343-351
Main Authors: Campian, Jian L., Piotrowski, Anna F., Ye, Xiaobu, Hakim, Frances T., Rose, Jeremy, Yan, Xiao-Yi, Lu, Yao, Gress, Ronald, Grossman, Stuart A.
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents, Alkylating - therapeutic use
Astrocytoma
Astrocytoma - blood
Astrocytoma - immunology
Astrocytoma - pathology
Astrocytoma - therapy
Cancer
CD4 antigen
CD8 antigen
Central Nervous System Neoplasms - blood
Central Nervous System Neoplasms - immunology
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - therapy
Chemoradiotherapy
Clinical Study
Dacarbazine - analogs & derivatives
Dacarbazine - therapeutic use
Dexamethasone
Female
Flow cytometry
Glioblastoma
Humans
Immune system
Longitudinal Studies
Lymphocyte receptors
Lymphocyte Subsets - drug effects
Lymphocyte Subsets - radiation effects
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphopenia
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neurology
Oncology
Prospective Studies
Temozolomide
Treatment Outcome
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Summary:The immune system plays a significant role in cancer prevention and outcome. In high grade astrocytomas (HGA), severe lymphopenia is associated with shortened survival due to tumor progression. This study was performed to quantify serial changes in lymphocyte subsets in HGA following standard radiation (RT) and temozolomide (TMZ). Adults (KPS >60, HIV negative) with newly diagnosed HGA scheduled to receive concurrent RT and TMZ and adjuvant TMZ were eligible. Blood was collected before beginning concurrent RT/TMZ and at weeks 6, 10, 18, and 26, and 3 months after completing adjuvant TMZ. Lymphocyte subsets were analyzed by flow cytometry. Twenty patients (70% glioblastoma, median age 53, 50% male, 80% Caucasian) who enrolled from January 2014 to August 2014 were followed until April 2016. Baseline dexamethasone dose was 0.5 mg/day and 15% had absolute lymphocyte counts (ALC) 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-017-2580-z