Characterization of co-existing colloidal structures in fasted state simulated fluids FaSSIF: A comparative study using AF4/MALLS, DLS and DOSY

•Colloidal structures in simulated intestinal fluids characterized by field-flow fractionation and DOSY-NMR.•Type of field-flow fractionation channel is of importance in preserving the colloidal structures.•Limitations of DLS and field-flow fractionation in analyzing biomimetic media were assessed....

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2017-10, Vol.145, p.531-536
Main Authors: Elvang, Philipp A., Stein, Paul C., Bauer-Brandl, Annette, Brandl, Martin
Format: Article
Language:English
Subjects:
Biomimetic
Biomimetic Materials - metabolism
Colloids - metabolism
Diffusion ordered spectroscopy
Drug Development - methods
Dynamic Light Scattering - methods
FaSSIF
Fasting
Field-flow fractionation
Fractionation, Field Flow - methods
Intestinal fluid
Intestinal Mucosa - metabolism
Intestinal Secretions - metabolism
Light scattering
Pharmaceutical Preparations - metabolism
Spectrum Analysis - methods
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Summary:•Colloidal structures in simulated intestinal fluids characterized by field-flow fractionation and DOSY-NMR.•Type of field-flow fractionation channel is of importance in preserving the colloidal structures.•Limitations of DLS and field-flow fractionation in analyzing biomimetic media were assessed.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2017.07.014