Serum level of orexin-A, leptin, adiponectin and insulin in north Indian obese women

•Orexin-A, insulin, leptin, adiponectin level in north Indian obese women.•Elisa of orexin-A, insulin, leptin, adiponectin level in north Indian obese women.•Body Mass index of north Indian obese women. Obesity is regulated by different metabolic factors like leptin, adiponectin insulin and neuropep...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2017-12, Vol.11, p.S1041-S1043
Main Authors: Mishra, Sameeksha, Gupta, Vani, Mishra, Supriya, Sachan, Rekha, Asthana, Akash
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - chemistry
Adult
Energy Metabolism
Female
Humans
Insulin
Insulin - blood
Leptin
Leptin - blood
Obesity
Obesity - blood
Orexin-A
Orexins - blood
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Summary:•Orexin-A, insulin, leptin, adiponectin level in north Indian obese women.•Elisa of orexin-A, insulin, leptin, adiponectin level in north Indian obese women.•Body Mass index of north Indian obese women. Obesity is regulated by different metabolic factors like leptin, adiponectin insulin and neuropeptide orexin-A. The aim of this study is to assess the role of these hormones and their interrelationship with obesity in north Indian women. A total of 168 obese women with Body Mass Index (BMI)>30kg/m2 and 150 lean women (BMI30kg/m2 (34.68±1.90). Orexin −A, leptin and adiponectin were estimated using quantitative sandwich enzyme linked immunoassay and insulin was estimated by using an immuno-radiometric assay. Orexin −A and adiponectin level were significantly lower however, leptin and inulin level were significantly higher in obese women as compared with control group. Further, the one- way group analysis showed that the orexin −A and adiponectin level were significantly lower but leptin and insulin level was significantly higher in obese women as compared to overweight and control group respectively. Result showed that the level of adiponectin, leptin, orexin-A and insulin play an important role in the regulation of energy expenditure. In obesity, the activity of these peptides is disturbed.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2017.07.037