Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats

Physiological concentrations of thyroid hormones are crucial for skeletal growth and development, physiological bone turnover and bone homeostasis maintenance. Methimazole (1-methyl-2-mercaptoimidazole) is an antithyroid drug used for the treatment of the hyperthyroidism in humans and animals. The a...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2017-10, Vol.94, p.124-128
Main Authors: Tatara, Marcin R., Gołyński, Marcin, Radzki, Radosław P., Bieńko, Marek, Krupski, Witold
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biomechanical Phenomena - drug effects
Densitometry
Femur
Femur - anatomy & histology
Femur - diagnostic imaging
Femur - drug effects
Femur - physiology
Male
Methimazole
Methimazole - administration & dosage
Methimazole - pharmacology
Quantitative computed tomography
Rat
Rats, Wistar
Tibia
Tibia - anatomy & histology
Tibia - diagnostic imaging
Tibia - drug effects
Tibia - physiology
Time Factors
Tomography, X-Ray Computed
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Summary:Physiological concentrations of thyroid hormones are crucial for skeletal growth and development, physiological bone turnover and bone homeostasis maintenance. Methimazole (1-methyl-2-mercaptoimidazole) is an antithyroid drug used for the treatment of the hyperthyroidism in humans and animals. The aim of the study was to determine effects of long-term oral methimazole treatment in male Wistar rats on biochemical bone metabolism markers, as well as morphological, geometric, densitometric and mechanical properties of femur and tibia. Experimental rats were subjected to 90-day-long oral treatment with 0.05% water solution of methimazole and were kept under identical environmental conditions and received the same diet ad libitum as the control group. Serum concentration of osteocalcin (OC) and C-terminal telopeptides of type I collagen (CTX-I) was determined. Femur and tibia were evaluated using quantitative computed tomography (QCT), peripheral QCT (pQCT) and three-point bending test. Final body weight of the experimental group was significantly decreased by 30% (P=0.01). Methimazole treatment significantly decreased serum OC concentration by 21% (P=0.02) and increased CTX-I concentration by 17% (P=0.06). Methimazole decreased morphological, geometric and densitometric parameters of femur and tibia in rats. Mechanical evaluation of bones has shown significantly decreased maximum elastic strength and ultimate strength of femur in rats treated with methimazole by 36% and 40% when compared to the control group (P
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.07.107