Concurrent hyperadrenocorticism and diabetes mellitus in dogs

Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and DM, and the risk factors involved that could contribute to the development of DM in dogs with HAC. A total of 235 dogs wi...

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Bibliographic Details
Published in:Research in veterinary science 2017-12, Vol.115, p.425-431
Main Authors: Miceli, D.D., Pignataro, O.P., Castillo, V.A.
Format: Article
Language:English
Subjects:
Adrenocortical Hyperfunction - complications
Adrenocortical Hyperfunction - pathology
Adrenocortical Hyperfunction - veterinary
Animals
Anticoagulants
Blood Glucose
Cholesterol
Coexistence
Cortisol
Diabetes
Diabetes mellitus
Diabetes Mellitus - pathology
Diabetes Mellitus - veterinary
Dog Diseases - pathology
Dogs
Fasting
Female
Females
Glucose
Hormones
Hyperadrenocorticism
Hypercortisolism
Hyperglycemia
Insulin resistance
Male
Metabolism
Pituitary
Risk analysis
Risk Factors
Survival
Triglycerides
Urine
Veterinary medicine
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Summary:Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and DM, and the risk factors involved that could contribute to the development of DM in dogs with HAC. A total of 235 dogs with HAC were studied and, according to their fasting glycemia, they were divided into three groups: 10.08mmol/L. The following parameters were evaluated: age, gender, cause of HAC, body condition, glycemia, total cholesterol, triglycerides, urinary cortisol:creatinin ratio (UCCR) and survival time. A 13.61% concurrence of HAC and DM was observed. Dogs with a fasting glycemia >5.6mmol/L, with dislipemia, with Pituitary-Dependent Hyperadrenocorticism, UCCR >100×10−6 and non-castrated females showed a higher risk of developing DM. The development of DM in dogs with HAC reduces the survival time. •Diabetes mellitus and hyperadrenocorticism in dogs are frequently associated.•Glycemia >5.6mmol/L increase the risk to develop diabetes mellitus.•UCCR >100×10−6 are associated with the high risk to develop diabetes mellitus.•Life expectancy are reduced in case of diabetes mellitus and hyperadrenocorticism.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2017.07.026