Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focus...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral research 2004, Vol.61 (1), p.67-70
Main Authors: Dereuddre-Bosquet, Nathalie, Roy, Béatrice, Routledge, Kate, Clayette, Pascal, Foucault, Georges, Lepoivre, Michel
Format: Article
Language:English
Subjects:
3TC
acivicin
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimetabolites - pharmacology
Antiviral agents
Biological and medical sciences
CTP synthetase
Deoxycytosine Nucleotides - biosynthesis
Deoxycytosine Nucleotides - metabolism
Drug Synergism
HIV
HIV-1 - drug effects
HIV-1 - growth & development
Human immunodeficiency virus 1
Humans
Isoxazoles - pharmacology
Lamivudine - metabolism
Lamivudine - pharmacology
Leukocytes, Mononuclear - virology
Medical sciences
PBMC
Pharmacology. Drug treatments
Phytohemagglutinins - metabolism
Virus Replication - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2003.08.002