Increased C4d and Bb immunoreactivity and decreased MBL immunoreactivity characterise first-time pathologic first-trimester miscarriage: a case-control study

The role of the complement system in first-time pathologic first-trimester miscarriage was investigated. In this case-control study, tissue samples of 126 women with pathologic miscarriage and termination of normal pregnancies were assessed. The pathologic pregnancy group consisted of 40 women with...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2018-01, Vol.38 (1), p.90-95
Main Authors: Canda, M. Tunc, Caglayan, Latife Doganay, Demir, Namik, Ortaç, Ragıp
Format: Article
Language:English
Subjects:
C4d
Complement
H score
MBL
Miscarriage
Pregnancy
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Summary:The role of the complement system in first-time pathologic first-trimester miscarriage was investigated. In this case-control study, tissue samples of 126 women with pathologic miscarriage and termination of normal pregnancies were assessed. The pathologic pregnancy group consisted of 40 women with missed miscarriage, 13 women with incomplete miscarriage and 10 women with a blighted ovum. The control group consisted of 63 normal-appearing pregnancies. Immunoreactivity for C4d, Bb and MBL was evaluated in the deciduas and villous trophoblasts separately using a semi-quantitative histological scoring system (H-score). C4d and Bb H-scores were higher and MBL H-score was reduced in the deciduas and villous tissues from pathologic miscarriage compared to termination of pregnancies (p = .003 and p = .001; p = .011 and p 
ISSN:0144-3615
1364-6893
DOI:10.1080/01443615.2017.1328589