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Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS
A strategy for rapid identification of the chemical constituents from crude extracts of Tribulus terrestris was proposed using an informatics platform for the UHPLC/Q-TOF MS E data analyses. This strategy mainly utilizes neutral losses, characteristic fragments, and in-house library to rapidly ident...
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| Published in: | Journal of the American Society for Mass Spectrometry 2017-11, Vol.28 (11), p.2302-2318 |
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| Main Authors: | , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c372t-92e8fbad4d857baa3dbee1d60200c2a102ccdd85a7ec81e832287bc5505ca56b3 |
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| cites | cdi_FETCH-LOGICAL-c372t-92e8fbad4d857baa3dbee1d60200c2a102ccdd85a7ec81e832287bc5505ca56b3 |
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| container_issue | 11 |
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| container_title | Journal of the American Society for Mass Spectrometry |
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| creator | Zheng, Wei Wang, Fangxu Zhao, Yang Sun, Xinguang Kang, Liping Fan, Ziquan Qiao, Lirui Yan, Renyi Liu, Shuchen Ma, Baiping |
| description | A strategy for rapid identification of the chemical constituents from crude extracts of
Tribulus terrestris
was proposed using an informatics platform for the UHPLC/Q-TOF MS
E
data analyses. This strategy mainly utilizes neutral losses, characteristic fragments, and in-house library to rapidly identify the structure of the compounds. With this strategy, rapid characterization of the chemical components of
T. terrestris
from Beijing, China was successfully achieved. A total of 82 steroidal saponins and nine flavonoids were identified or tentatively identified from
T. terrestris
. Among them, 15 new components were deduced based on retention times and characteristic MS fragmentation patterns. Furthermore, the chemical components of
T. terrestris
, including the other two samples from Xinjiang Uygur Autonomous region, China, and Rome, Italy, were also identified with this strategy. Altogether, 141 chemical components were identified from these three samples, of which 39 components were identified or tentatively identified as new compounds, including 35 groups of isomers. It demonstrated that this strategy provided an efficient protocol for the rapid identification of chemical constituents in complex samples such as traditional Chinese medicines (TCMs) by UHPLC/Q-TOF MS
E
with informatics platform.
Graphical Abstract
ᅟ |
| doi_str_mv | 10.1007/s13361-017-1761-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1925513977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1952066650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-92e8fbad4d857baa3dbee1d60200c2a102ccdd85a7ec81e832287bc5505ca56b3</originalsourceid><addsrcrecordid>eNp1kU1P3DAQhi0EKpT2B3CpLHHhkjJjr-PkiAJ0Ky3io8vZsh2HGu0mi50c6K_voAVUVeI0I80z73y8jB0hfEcAfZpRyhILQF2gpkTtsAOsdF0gCrlLOcxmBUhQ--xzzo9AINT6E9sXlS5LxNkBe7izm9jy5rdN1o8hxT92jEPPh443Q5_HOE6hHzOPPV-m6KbVlDlhKeQxxcy7NKz5eey6kAjjc-viaAl3z_x-frNoTm-L5fUlv_r1he11dpXD19d4yO4vL5bNvFhc__jZnC0KL7UYi1qEqnO2nbWV0s5a2boQsC1BAHhhEYT3LdWsDr7CUElBpzivFChvVenkITvZ6m7S8DTRlmYdsw-rle3DMGWDtVAKZa01ocf_oY_DlHrajigloCxLBUThlvJpyDmFzmxSXNv0bBDMiwtm64Kh55oXF4yinm-vypNbh_a94-3tBIgtkKnUP4T0z-gPVf8CZvuR8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1952066650</pqid></control><display><type>article</type><title>Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)</source><creator>Zheng, Wei ; Wang, Fangxu ; Zhao, Yang ; Sun, Xinguang ; Kang, Liping ; Fan, Ziquan ; Qiao, Lirui ; Yan, Renyi ; Liu, Shuchen ; Ma, Baiping</creator><creatorcontrib>Zheng, Wei ; Wang, Fangxu ; Zhao, Yang ; Sun, Xinguang ; Kang, Liping ; Fan, Ziquan ; Qiao, Lirui ; Yan, Renyi ; Liu, Shuchen ; Ma, Baiping</creatorcontrib><description>A strategy for rapid identification of the chemical constituents from crude extracts of
Tribulus terrestris
was proposed using an informatics platform for the UHPLC/Q-TOF MS
E
data analyses. This strategy mainly utilizes neutral losses, characteristic fragments, and in-house library to rapidly identify the structure of the compounds. With this strategy, rapid characterization of the chemical components of
T. terrestris
from Beijing, China was successfully achieved. A total of 82 steroidal saponins and nine flavonoids were identified or tentatively identified from
T. terrestris
. Among them, 15 new components were deduced based on retention times and characteristic MS fragmentation patterns. Furthermore, the chemical components of
T. terrestris
, including the other two samples from Xinjiang Uygur Autonomous region, China, and Rome, Italy, were also identified with this strategy. Altogether, 141 chemical components were identified from these three samples, of which 39 components were identified or tentatively identified as new compounds, including 35 groups of isomers. It demonstrated that this strategy provided an efficient protocol for the rapid identification of chemical constituents in complex samples such as traditional Chinese medicines (TCMs) by UHPLC/Q-TOF MS
E
with informatics platform.
Graphical Abstract
ᅟ</description><identifier>ISSN: 1044-0305</identifier><identifier>EISSN: 1879-1123</identifier><identifier>DOI: 10.1007/s13361-017-1761-5</identifier><identifier>PMID: 28766114</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analytical Chemistry ; Bioinformatics ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chromatography, High Pressure Liquid - methods ; Constituents ; Flavonoids ; Flavonoids - analysis ; Flavonoids - chemistry ; Fragments ; Informatics ; Isomers ; Libraries ; Mass spectrometry ; Mass Spectrometry - methods ; Organic Chemistry ; Plant Extracts - chemistry ; Proteomics ; Research Article ; Saponins ; Saponins - analysis ; Saponins - chemistry ; Strategy ; Traditional Chinese medicine ; Tribulus - chemistry</subject><ispartof>Journal of the American Society for Mass Spectrometry, 2017-11, Vol.28 (11), p.2302-2318</ispartof><rights>American Society for Mass Spectrometry 2017</rights><rights>Journal of The American Society for Mass Spectrometry is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-92e8fbad4d857baa3dbee1d60200c2a102ccdd85a7ec81e832287bc5505ca56b3</citedby><cites>FETCH-LOGICAL-c372t-92e8fbad4d857baa3dbee1d60200c2a102ccdd85a7ec81e832287bc5505ca56b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28766114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Wang, Fangxu</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Sun, Xinguang</creatorcontrib><creatorcontrib>Kang, Liping</creatorcontrib><creatorcontrib>Fan, Ziquan</creatorcontrib><creatorcontrib>Qiao, Lirui</creatorcontrib><creatorcontrib>Yan, Renyi</creatorcontrib><creatorcontrib>Liu, Shuchen</creatorcontrib><creatorcontrib>Ma, Baiping</creatorcontrib><title>Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS</title><title>Journal of the American Society for Mass Spectrometry</title><addtitle>J. Am. Soc. Mass Spectrom</addtitle><addtitle>J Am Soc Mass Spectrom</addtitle><description>A strategy for rapid identification of the chemical constituents from crude extracts of
Tribulus terrestris
was proposed using an informatics platform for the UHPLC/Q-TOF MS
E
data analyses. This strategy mainly utilizes neutral losses, characteristic fragments, and in-house library to rapidly identify the structure of the compounds. With this strategy, rapid characterization of the chemical components of
T. terrestris
from Beijing, China was successfully achieved. A total of 82 steroidal saponins and nine flavonoids were identified or tentatively identified from
T. terrestris
. Among them, 15 new components were deduced based on retention times and characteristic MS fragmentation patterns. Furthermore, the chemical components of
T. terrestris
, including the other two samples from Xinjiang Uygur Autonomous region, China, and Rome, Italy, were also identified with this strategy. Altogether, 141 chemical components were identified from these three samples, of which 39 components were identified or tentatively identified as new compounds, including 35 groups of isomers. It demonstrated that this strategy provided an efficient protocol for the rapid identification of chemical constituents in complex samples such as traditional Chinese medicines (TCMs) by UHPLC/Q-TOF MS
E
with informatics platform.
Graphical Abstract
ᅟ</description><subject>Analytical Chemistry</subject><subject>Bioinformatics</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Constituents</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - chemistry</subject><subject>Fragments</subject><subject>Informatics</subject><subject>Isomers</subject><subject>Libraries</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Organic Chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Proteomics</subject><subject>Research Article</subject><subject>Saponins</subject><subject>Saponins - analysis</subject><subject>Saponins - chemistry</subject><subject>Strategy</subject><subject>Traditional Chinese medicine</subject><subject>Tribulus - chemistry</subject><issn>1044-0305</issn><issn>1879-1123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kU1P3DAQhi0EKpT2B3CpLHHhkjJjr-PkiAJ0Ky3io8vZsh2HGu0mi50c6K_voAVUVeI0I80z73y8jB0hfEcAfZpRyhILQF2gpkTtsAOsdF0gCrlLOcxmBUhQ--xzzo9AINT6E9sXlS5LxNkBe7izm9jy5rdN1o8hxT92jEPPh443Q5_HOE6hHzOPPV-m6KbVlDlhKeQxxcy7NKz5eey6kAjjc-viaAl3z_x-frNoTm-L5fUlv_r1he11dpXD19d4yO4vL5bNvFhc__jZnC0KL7UYi1qEqnO2nbWV0s5a2boQsC1BAHhhEYT3LdWsDr7CUElBpzivFChvVenkITvZ6m7S8DTRlmYdsw-rle3DMGWDtVAKZa01ocf_oY_DlHrajigloCxLBUThlvJpyDmFzmxSXNv0bBDMiwtm64Kh55oXF4yinm-vypNbh_a94-3tBIgtkKnUP4T0z-gPVf8CZvuR8A</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Zheng, Wei</creator><creator>Wang, Fangxu</creator><creator>Zhao, Yang</creator><creator>Sun, Xinguang</creator><creator>Kang, Liping</creator><creator>Fan, Ziquan</creator><creator>Qiao, Lirui</creator><creator>Yan, Renyi</creator><creator>Liu, Shuchen</creator><creator>Ma, Baiping</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS</title><author>Zheng, Wei ; 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Am. Soc. Mass Spectrom</stitle><addtitle>J Am Soc Mass Spectrom</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>28</volume><issue>11</issue><spage>2302</spage><epage>2318</epage><pages>2302-2318</pages><issn>1044-0305</issn><eissn>1879-1123</eissn><abstract>A strategy for rapid identification of the chemical constituents from crude extracts of
Tribulus terrestris
was proposed using an informatics platform for the UHPLC/Q-TOF MS
E
data analyses. This strategy mainly utilizes neutral losses, characteristic fragments, and in-house library to rapidly identify the structure of the compounds. With this strategy, rapid characterization of the chemical components of
T. terrestris
from Beijing, China was successfully achieved. A total of 82 steroidal saponins and nine flavonoids were identified or tentatively identified from
T. terrestris
. Among them, 15 new components were deduced based on retention times and characteristic MS fragmentation patterns. Furthermore, the chemical components of
T. terrestris
, including the other two samples from Xinjiang Uygur Autonomous region, China, and Rome, Italy, were also identified with this strategy. Altogether, 141 chemical components were identified from these three samples, of which 39 components were identified or tentatively identified as new compounds, including 35 groups of isomers. It demonstrated that this strategy provided an efficient protocol for the rapid identification of chemical constituents in complex samples such as traditional Chinese medicines (TCMs) by UHPLC/Q-TOF MS
E
with informatics platform.
Graphical Abstract
ᅟ</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28766114</pmid><doi>10.1007/s13361-017-1761-5</doi><tpages>17</tpages></addata></record> |
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| ispartof | Journal of the American Society for Mass Spectrometry, 2017-11, Vol.28 (11), p.2302-2318 |
| issn | 1044-0305 1879-1123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1925513977 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Analytical Chemistry Bioinformatics Biotechnology Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Constituents Flavonoids Flavonoids - analysis Flavonoids - chemistry Fragments Informatics Isomers Libraries Mass spectrometry Mass Spectrometry - methods Organic Chemistry Plant Extracts - chemistry Proteomics Research Article Saponins Saponins - analysis Saponins - chemistry Strategy Traditional Chinese medicine Tribulus - chemistry |
| title | Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS |
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