ANTIOXIDANT DEFENSE MECHANISMS AND THE TOXICITY OF FIBROUS AND NONFIBROUS PARTICLES

The respiratory tract is exposed continually to an external environment containing oxidant pollutants, cigarette smoke, and particles. The enzymatic and nonenzymatic antioxidant defense mechanisms in the respiratory tract are described, along with the relationship between particles and oxidative str...

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Bibliographic Details
Published in:Inhalation toxicology 2002, Vol.14 (1), p.101-118
Main Authors: Driscoll, Kevin E., Carter, Janet M., Borm, Paul J. A.
Format: Article
Language:English
Subjects:
Animals
Asbestos - toxicity
Free Radical Scavengers - metabolism
Humans
Metals - toxicity
Oxidative Stress - physiology
Particle Size
Reactive Oxygen Species - metabolism
Respiratory System - drug effects
Respiratory System - enzymology
Respiratory System - metabolism
Silicon Dioxide - toxicity
Species Specificity
Superoxide Dismutase - metabolism
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Summary:The respiratory tract is exposed continually to an external environment containing oxidant pollutants, cigarette smoke, and particles. The enzymatic and nonenzymatic antioxidant defense mechanisms in the respiratory tract are described, along with the relationship between particles and oxidative stress and particle induction of antioxidant defenses. The antioxidant response is considered in terms of its importance for risk evaluation.
ISSN:0895-8378
1091-7691
DOI:10.1080/089583701753338668